PLX3397 treatment inhibits constitutive CSF1R-induced oncogenic ERK signaling, reduces tumor growth, and metastatic burden in osteosarcoma.
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DOI: 10.1016/j.bone.2020.115353
Abstract: Osteosarcoma (OSA) is a heterogeneous and aggressive solid tumor of the bone. We recently identified the colony stimulating factor 1 receptor (Csf1r) gene as a novel driver of osteosarcomagenesis in mice using the Sleeping Beauty… read more here.
Keywords: tumor; plx3397 treatment; csf1r; csf1r csf1 ... See more keywords