To Kill a Microglia: A Case for CSF1R Inhibitors.
Sign Up to like & getrecommendations! Published in 2020 at "Trends in immunology"
DOI: 10.1016/j.it.2020.07.001
Abstract: Microglia, the brain's immune sentinels, have garnered much attention in recent years. Researchers have begun to identify the manifold roles that these cells play in the central nervous system (CNS), and this work has been… read more here.
Keywords: csf1r; case csf1r; microglia case; csf1r inhibitors ... See more keywords
Identification of Selective Imidazopyridine CSF1R Inhibitors.
Sign Up to like & getrecommendations! Published in 2024 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.4c00110
Abstract: Colony stimulating factor-1 receptor (CSF1R or c-FMS), a class III receptor tyrosine kinase expressed on members of the mononuclear phagocyte system (MPS), plays a key role in the proper functioning of macrophages, microglia, and related… read more here.
Keywords: csf1r; chemistry; csf1r inhibitors; identification selective ... See more keywords
Evaluating Triazole-Substituted Pyrrolopyrimidines as CSF1R Inhibitors
Sign Up to like & getrecommendations! Published in 2025 at "Molecules"
DOI: 10.3390/molecules30122641
Abstract: 6-Aryl-7H-pyrrolo[2,3-d]pyrimidin-4-amines have promising properties as colony-stimulating factor 1 receptor (CSF1R) inhibitors. Inspired by these antagonists, two series of 1,2,3-triazole analogues (28 compounds) were synthesized and evaluated as CSF1R inhibitors. Enzymatic IC50 profiling showed that 27… read more here.
Keywords: triazole substituted; pyrrolopyrimidines csf1r; substituted pyrrolopyrimidines; evaluating triazole ... See more keywords