G‐CSF Receptor Deletion Amplifies Cortical Bone Dysfunction in Mice With STAT3 Hyperactivation in Osteocytes
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4654
Abstract: Bone strength is determined by the structure and composition of its thickened outer shell (cortical bone), yet the mechanisms controlling cortical consolidation are poorly understood. Cortical bone maturation depends on SOCS3‐mediated suppression of IL‐6 cytokine‐induced… read more here.
Keywords: dmp1cre socs3f; csf3r; bone; cortical bone ... See more keywords
G‐CSF administration favours SDF‐1 release and activation of neutrophils and monocytes in recipients of autologous peripheral blood progenitor cells
Sign Up to like & getrecommendations! Published in 2019 at "Cytokine"
DOI: 10.1016/j.cyto.2018.12.011
Abstract: Graphical abstract Figure. No Caption available. HighlightsSDF‐1 level correlates with G‐CSF concentration after mobilization.Number of neutrophils and monocytes increases in response to G‐CSF.Percentage of CSF3R+ cells decreases during mobilization. ABSTRACT G‐CSF is a growth factor… read more here.
Keywords: neutrophils monocytes; mobilisation; csf administration; csf ... See more keywords
Altered expression of CSF3R splice variants impacts signal response and is associated with SRSF2 mutations
Sign Up to like & getrecommendations! Published in 2019 at "Leukemia"
DOI: 10.1038/s41375-019-0567-9
Abstract: Three annotated CSF3R mRNA splice variants have been described. CSF3R-V1 is the wild-type receptor, while CSF3R-V4 is a truncated form increased in some patients with AML. CSF3R-V3 mRNA was identified in placenta more than 20… read more here.
Keywords: splice variants; expression csf3r; expression; csf3r ... See more keywords
Myeloid-Lineage Enhancers Drive Oncogene Synergy and Represent a Novel Therapeutic Target in CSF3R-CEBPA Mutant AML
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DOI: 10.1182/blood-2019-124773
Abstract: Acute Myeloid Leukemia (AML) results from the stepwise accumulation of mutations from distinct functional classes, ultimately culminating in malignant transformation. Based on their oncogenic activity, mutations can be classified into three distinct groups. Class I… read more here.
Keywords: cebpa; membership entity; csf3r; differentiation ... See more keywords
Prognostic Impact of CSF3R Mutations in Favorable Risk Childhood Acute Myeloid Leukemia.
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood.2019004179
Abstract: Truncation mutations in the granulocyte colony-stimulating factor receptor gene (CSF3R) are a rare abnormality in pediatric acute myeloid leukemia, and are usually associated either with mutations in CEBPA or with t(8;21). Through sequencing of over… read more here.
Keywords: myeloid leukemia; favorable risk; csf3r; acute myeloid ... See more keywords
Coexisting of bone marrow fibrosis, dysplasia and an X chromosomal abnormality in chronic neutrophilic leukemia with CSF3R mutation: a case report and literature review
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DOI: 10.1186/s12885-018-4236-6
Abstract: BackgroundChronic neutrophilic leukemia (CNL) is a rare myeloproliferative neoplasm (MPN) with less than 40 cases of patients being reported or clinically suspected meeting with 2008 World Health Organization (“WHO”) diagnostic criteria. The current diagnosis of… read more here.
Keywords: marrow fibrosis; bone marrow; csf3r; mutation ... See more keywords
Clinical significance of CSF3R, SRSF2 and SETBP1 mutations in chronic neutrophilic leukemia and chronic myelomonocytic leukemia
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DOI: 10.18632/oncotarget.15355
Abstract: Chronic neutrophilic leukemia (CNL) and chronic myelomonocytic leukemia (CMML) are rare hematologic neoplasms. We performed CSF3R, SRSF2 and SETBP1 mutational analyses in 10 CNL and 56 CMML patients. In this sample cohort, 80% of CNL… read more here.
Keywords: cmml patients; setbp1; srsf2; csf3r ... See more keywords
Co-Occurring CSF3R W791* Germline and Somatic T618I Driver Mutations Induce Early CNL and Clonal Progression to Mixed Phenotype Acute Leukemia
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DOI: 10.3390/curroncol29020068
Abstract: Chronic neutrophilic leukemia (CNL) relates to mutational CSF3R activation with membrane proximal CSF3R mutations such as T618I as driver mutations, but the significance of truncating mutations is not clarified. In CNL, concomitant mutations promote disease… read more here.
Keywords: t618i; germline somatic; csf3r; leukemia ... See more keywords