Genetics of Osteonecrosis in Children and Adults with Systemic Lupus Erythematosus.
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DOI: 10.1093/rheumatology/kead016
Abstract: OBJECTIVES Genetics play an important role in SLE risk, as well as osteonecrosis (ON), a significant and often debilitating complication of SLE. We aimed to identify genetic risk loci for ON in people with childhood-onset… read more here.
Keywords: osteonecrosis children; children adults; genetics osteonecrosis; csle asle ... See more keywords
European evidence-based recommendations for diagnosis and treatment of childhood-onset systemic lupus erythematosus: the SHARE initiative
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DOI: 10.1136/annrheumdis-2016-210960
Abstract: Childhood-onset systemic lupus erythematosus (cSLE) is a rare, multisystem and potentially life-threatening autoimmune disorder with significant associated morbidity. Evidence-based guidelines are sparse and management is often based on clinical expertise. SHARE (Single Hub and Access… read more here.
Keywords: based recommendations; diagnosis treatment; evidence; csle ... See more keywords
Safety and immunogenicity of the quadrivalent human papillomavirus vaccine in patients with childhood systemic lupus erythematosus: a real-world interventional multi-centre study
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DOI: 10.1177/0961203320928406
Abstract: Objective This study aimed to assess the safety and immunogenicity of the quadrivalent human papillomavirus (qHPV) vaccination in childhood-onset systemic lupus erythematosus (cSLE) patients. Methods Volunteer cSLE patients aged 9–20 years and healthy controls (HC)… read more here.
Keywords: csle patients; study; safety immunogenicity; three dose ... See more keywords
Multi-pronged approach to enhance education of children and adolescents with lupus, caregivers, and healthcare providers in New Jersey: Needs assessment, evaluation, and development of educational materials
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DOI: 10.1177/0961203320969975
Abstract: Background Childhood Systemic Lupus Erythematosus (cSLE) patients are younger at diagnosis and have a more severe disease course compared to adult onset SLE patients and develop significant complications related to disease and or immunosuppression. Moreover,… read more here.
Keywords: needs assessment; healthcare providers; children adolescents; csle ... See more keywords
Risk factors for mortality in 1528 Brazilian childhood-onset systemic lupus erythematosus patients
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DOI: 10.1177/09612033231170515
Abstract: Objectives To identify associations between mortality in cSLE patients and their characteristics: clinical and laboratory features, disease activity and damage scores, and treatment; to evaluate risk factors associated with mortality in cSLE; and to determine… read more here.
Keywords: factors mortality; risk factors; mortality; lupus ... See more keywords
Changes in Frequency and Activation Status of Major CD4+ T-Cell Subsets after Initiation of Immunosuppressive Therapy in a Patient with New Diagnosis Childhood-Onset Systemic Lupus Erythematosus
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DOI: 10.3389/fped.2017.00104
Abstract: Background Several studies suggest that defects of regulatory T-cells (Tregs) and impaired cellular immunity are secondary to an imbalance between auto-aggressive T-cells and Tregs in lupus patients. Discrepancies in Tregs and effector T-cells (Teff) in… read more here.
Keywords: disease activity; cd4; csle; csle patient ... See more keywords