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   Articles with "csn5" as a keyword



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CSN5 controls the growth of osteosarcoma via modulating the EGFR/PI3K/Akt axis.

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recommendations! Published in 2019 at "Experimental cell research"

DOI: 10.1016/j.yexcr.2019.111646

Abstract: CSN5, a critical subunit of the constitutive photomorphogenesis 9 (COP9) signalosome (CSN), functions as a potential tumor promoter in various cancers. However, the biological functions and clinical significance of CSN5 in osteosarcoma (OS) remains unclear.… read more here.

Keywords: growth; osteosarcoma; csn5; pi3k akt ... See more keywords
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Stat3 Contributes to Cancer Progression by Regulating Jab1/Csn5 Expression

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recommendations! Published in 2017 at "Oncogene"

DOI: 10.1038/onc.2016.271

Abstract: Our previous studies demonstrated that Jab1/Csn5 overexpression is correlated with low survival rates in cancer patients, including nasopharyngeal carcinoma (NPC), breast cancer and hepatocellular carcinoma, and contributes to NPC’s resistance to radiotherapy and cisplatin by… read more here.

Keywords: cancer; jab1 csn5; csn5 expression; csn5 ... See more keywords
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Prognostic and therapeutic significance of COP9 signalosome subunit CSN5 in prostate cancer

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recommendations! Published in 2021 at "Oncogene"

DOI: 10.1038/s41388-021-02118-4

Abstract: Chromosome 8q gain is associated with poor clinical outcomes in prostate cancer, but the underlying biological mechanisms remain to be clarified. CSN5, a putative androgen receptor (AR) partner that is located on chromosome 8q, is… read more here.

Keywords: cancer; significance; cop9 signalosome; prostate cancer ... See more keywords
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COP9 signalosome subunit CSN5, but not CSN6, is upregulated in lung adenocarcinoma and predicts poor prognosis.

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recommendations! Published in 2018 at "Journal of thoracic disease"

DOI: 10.21037/jtd.2018.02.09

Abstract: Background The COP9 signalosome (CSN) is an evolutionarily conserved complex composed of eight subunits (CSN1-CSN8). Among the CSN subunits, CSN5 and its dimerization partner CSN6 are the only two MPN (Mpr1-Pad1-N-terminal) domain-containing subunits. These two… read more here.

Keywords: cop9 signalosome; csn5 csn6; lung cancer; csn5 ... See more keywords