Oral Administration of a Specific p300/CBP Lysine Acetyltransferase Activator Induces Synaptic Plasticity and Repairs Spinal Cord Injury.
Sign Up to like & getrecommendations! Published in 2024 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.4c00124
Abstract: TTK21 is a small-molecule activator of p300/creb binding protein (CBP) acetyltransferase activity, which, upon conjugation with a glucose-derived carbon nanosphere (CSP), can efficiently cross the blood-brain barrier and activate histone acetylation in the brain. Its… read more here.
Keywords: oral administration; spinal cord; csp ttk21; administration ... See more keywords
Epigenetic modulation rescues neurodevelopmental deficits in Syngap1+/− mice
Sign Up to like & getrecommendations! Published in 2025 at "Aging Cell"
DOI: 10.1111/acel.14408
Abstract: SYNGAP1 is a Ras GTPase‐activating protein that plays a crucial role during brain development and in synaptic plasticity. Sporadic heterozygous mutations in SYNGAP1 affect social and emotional behaviour observed in intellectual disability (ID) and autism… read more here.
Keywords: p300 cbp; csp ttk21; syngap1; syngap1 mice ... See more keywords
Reinstating plasticity and memory in a tauopathy mouse model with an acetyltransferase activator
Sign Up to like & getrecommendations! Published in 2018 at "EMBO Molecular Medicine"
DOI: 10.15252/emmm.201708587
Abstract: Chromatin acetylation, a critical regulator of synaptic plasticity and memory processes, is thought to be altered in neurodegenerative diseases. Here, we demonstrate that spatial memory and plasticity (LTD, dendritic spine formation) deficits can be restored… read more here.
Keywords: activator; csp ttk21; plasticity memory; mouse model ... See more keywords