Tandem Remote Csp3–H Activation/Csp3–Csp3 Cleavage in Unstrained Aliphatic Chains Assisted by Palladium(II)
Sign Up to like & getrecommendations! Published in 2019 at "Organometallics"
DOI: 10.1021/acs.organomet.8b00920
Abstract: We report here a proof-of-concept for the cleavage of unstrained remote Csp3–Csp3 bonds at room temperature assisted by a directing group, opening up new possibilities to use aliphatic carboxylic acids as suitable alkenyl coupling partners.… read more here.
Keywords: cleavage; csp3 activation; cleavage unstrained; csp3 ... See more keywords
Palladium-Catalyzed Enantioselective Csp3-Csp3 Cross-Coupling for the Synthesis of (Poly)fluorinated Chiral Building Blocks.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.8b02369
Abstract: A general method for the enantioselective synthesis of carbo- and heterocyclic carbonyl compounds bearing fluorinated α-tetrasubstituted stereocenters using palladium-catalyzed decarboxylative allylic alkylation is described. The stereoselective Csp3-Csp3 cross-coupling reaction delivers five- and six-membered ketone and… read more here.
Keywords: csp3 csp3; csp3 cross; csp3; palladium catalyzed ... See more keywords
Visible-Light-Mediated Sulfonylimination of Tertiary Amines with Sulfonylazides Involving Csp3-Csp3 Bond Cleavage.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b00786
Abstract: Visible-light-induced cross-coupling of arylsulfonyl azides with tertiaryamines in the presence of Eosin Y at room temperature has been achieved. This transformation features alkyl C-C bond cleavage and provides a green approach to N-sulfonylamidines under mild… read more here.
Keywords: csp3; light mediated; visible light; bond cleavage ... See more keywords
Nickel-Catalyzed Reductive Dicarbofunctionalization of Alkenes.
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DOI: 10.1021/jacs.7b03195
Abstract: An intermolecular, three-component reductive dicarbofunctionalization of alkenes is presented here. The combination of Ni catalysis with TDAE as final reductant enables the direct formation of Csp3-Csp3 and Csp3-Csp2 bonds across a variety of π-systems using… read more here.
Keywords: catalyzed reductive; csp3; nickel catalyzed; reductive dicarbofunctionalization ... See more keywords
Recent progress in the oxidative coupling of unactivated Csp3-H bonds with other C-H bonds.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical communications"
DOI: 10.1039/d1cc04802c
Abstract: The oxidative coupling between two carbon-hydrogen (C-H) bonds offers the most straightforward pathway to construct C-C bonds from hydrocarbons without pre-functionalization, exhibiting high step- and atom-economy. This article features the recent advances in the oxidative… read more here.
Keywords: coupling unactivated; csp3 bonds; unactivated csp3; csp3 ... See more keywords
Recent advances in radical enabled selective Csp3-F bond activation of multifluorinated compounds.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d1cc06446k
Abstract: Fluorine-containing molecules have found broad applications in pharmaceutical and agrochemical industries as introducing fluorine into a molecule could significantly tune the biological activities of parent molecules. Thus, the synthesis of fluorine-containing molecules has received substantial… read more here.
Keywords: csp3; enabled selective; selective csp3; multifluorinated compounds ... See more keywords
Expandability of the Covalent Bond: A New Facet Discovered in Extremely Long Csp3-Csp3 Single Bonds
Sign Up to like & getrecommendations! Published in 2020 at "Bulletin of the Chemical Society of Japan"
DOI: 10.1246/bcsj.20200374
Abstract: Molecules with an extreme structural parameter, such as an elongated C-C bond, have attracted much attention due to their special properties, which ordinary molecules do not have. Stabilized hexaph... read more here.
Keywords: bond; covalent bond; csp3; new facet ... See more keywords