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   Articles with "cspg4" as a keyword



Anti-CSPG4 DNA vaccination as a promising strategy for the treatment of CSPG4+ tumours: A comparative oncology trial

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recommendations! Published in 2019 at "Annals of Oncology"

DOI: 10.1093/annonc/mdz253.043

Abstract: Abstract Background Among the most interesting targets for immunotherapeutic approaches, the Chondroitin Sulfate Proteoglycan (CSPG)4 stands out, with low expression in healthy tissues, high expression in several solid tumors and a key role in cancer… read more here.

Keywords: hudo cspg4; cspg4 dna; cspg4; canine ... See more keywords

CSPG4 Involvement in Endometrial Decidualization Contributes to the Pathogenesis of Preeclampsia

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recommendations! Published in 2024 at "Biology of Reproduction"

DOI: 10.1093/biolre/ioae167

Abstract: Abstract Preeclampsia (PE) is a condition of pregnancy in which symptoms of hypertension develop after 20 weeks of gestation. it can lead to placental dysfunction, maternal and perinatal mortality and morbidity. The incidence of PE… read more here.

Keywords: role; cspg4; cspg4 expression; decidualization ... See more keywords

CSPG4-dependent cytotoxicity for C. difficile TcdB is influenced by extracellular calcium and chondroitin sulfate

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recommendations! Published in 2024 at "mSphere"

DOI: 10.1128/msphere.00094-24

Abstract: ABSTRACT TcdB is an intracellular bacterial toxin indispensable to Clostridioides difficile infections. The ability to use chondroitin sulfate proteoglycan 4 (CSPG4) as a primary cell surface receptor is evolutionarily conserved by the two major variants… read more here.

Keywords: chondroitin sulfate; receptor; cspg4; cell ... See more keywords
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MMP-13 Regulates Matrix Binding and Internalization of NG2/CSGP4 in Mandibular Fibrochondrocytes

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recommendations! Published in 2023 at "Physiology"

DOI: 10.1152/physiol.2023.38.s1.5731478

Abstract: Objective: Post-traumatic osteoarthritis (OA) is associated with cartilage degradation resulting in changes in cell-matrix mediated signaling after injury. Matrix metalloproteinase-13 (MMP13) is a critical enzyme in this process, degrading the extracellular matrix and modifying receptors.… read more here.

Keywords: matrix binding; mandibular fibrochondrocytes; ng2 cspg4; internalization ... See more keywords

A Linarin Derivative Protects against Ischemia-Induced Neuronal Injury in Mice by Promoting Cerebral Blood Flow Recovery via KDELR-Dependent CSPG4 Activation

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recommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"

DOI: 10.1155/2022/6434086

Abstract: The cerebral ischemic microvascular response and collateral circulation compensatory capacity are important for the outcome of ischemic stroke. Here, we sought to evaluate the effect of a linarin derivate 4′-benzylapigenin-7-β-rutinoside (BLR) on neurological function and… read more here.

Keywords: kdelr; cerebral blood; blood flow; cspg4 ... See more keywords

Structural dynamics of receptor recognition and pH-induced dissociation of full-length Clostridioides difficile Toxin B

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recommendations! Published in 2022 at "PLoS Biology"

DOI: 10.1371/journal.pbio.3001589

Abstract: Clostridioides difficile secretes Toxin B (TcdB) as one of its major virulence factors, which binds to intestinal epithelial and subepithelial receptors, including frizzled proteins and chondroitin sulfate proteoglycan 4 (CSPG4). Here, we present cryo-EM structures… read more here.

Keywords: full length; dynamics receptor; clostridioides difficile; cspg4 ... See more keywords

CSPG4: A Target for Selective Delivery of Human Cytolytic Fusion Proteins and TRAIL

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recommendations! Published in 2017 at "Biomedicines"

DOI: 10.3390/biomedicines5030037

Abstract: Chondroitin-sulfate proteoglycan 4 (CSPG4) is a transmembrane glycoprotein overexpressed on malignant cells in several cancer types with only limited expression on normal cells. CSPG4 is implicated in several signaling pathways believed to drive cancer progression,… read more here.

Keywords: fusion proteins; cspg4; target; cancer ... See more keywords

CSPG4 Expression in GIST Is Associated with Better Prognosis and Strong Cytotoxic Immune Response

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recommendations! Published in 2022 at "Cancers"

DOI: 10.3390/cancers14051306

Abstract: Simple Summary Gastrointestinal stromal tumors (GIST) are the most frequent sarcomas of the gastrointestinal tract. Identification of novel prognostic and/or therapeutic targets is a major issue to overcome tyrosine kinase inhibitors resistances. CSPG4, a cell… read more here.

Keywords: gist; cspg4; expression; cspg4 expression ... See more keywords

Decitabine-Mediated Upregulation of CSPG4 in Ovarian Carcinoma Cells Enables Targeting by CSPG4-Specific CAR-T Cells

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recommendations! Published in 2022 at "Cancers"

DOI: 10.3390/cancers14205033

Abstract: Simple Summary Cancer therapy by specifically redirected T cells has revolutionized the field of oncology. However, the repertoire of targetable antigens is small. Here, we use the FDA-approved drug decitabine to upregulate the surface antigen… read more here.

Keywords: cspg4; car; carcinoma cells; ovarian carcinoma ... See more keywords

The Significance of Chondroitin Sulfate Proteoglycan 4 (CSPG4) in Human Gliomas

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recommendations! Published in 2018 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms19092724

Abstract: Neuron glial antigen 2 (NG2) is a chondroitin sulphate proteoglycan 4 (CSPG4) that occurs in developing and adult central nervous systems (CNSs) as a marker of oligodendrocyte precursor cells (OPCs) together with platelet-derived growth factor… read more here.

Keywords: chondroitin; cspg4; proteoglycan cspg4; human gliomas ... See more keywords

VT68.2: An Antibody to Chondroitin Sulfate Proteoglycan 4 (CSPG4) Displays Reactivity against a Tumor-Associated Carbohydrate Antigen

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recommendations! Published in 2023 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms24032506

Abstract: The anti-CSPG4 monoclonal antibodies (mAbs) have shown anti-tumor activity and therapeutic potential for treating breast cancer. In addition, CSPG4 is a dominant tumor-associated antigen that is also involved in normal-tissue development in humans. Therefore, the… read more here.

Keywords: anti cspg4; cspg4; carbohydrate; reactivity ... See more keywords