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   Articles with "cstf2" as a keyword



Human CSTF2 RNA Recognition Motif Domain Binds to a U-Rich RNA Sequence through a Multistep Binding Process

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recommendations! Published in 2024 at "Biochemistry"

DOI: 10.1021/acs.biochem.4c00408

Abstract: The RNA recognition motif (RRM) is a conserved and ubiquitous RNA-binding domain that plays essential roles in mRNA splicing, polyadenylation, transport, and stability. RRM domains exhibit remarkable diversity in binding partners, interacting with various sequences… read more here.

Keywords: cstf2; rna; rich rna; rrm ... See more keywords

CSTF2-Induced Shortening of the RAC1 3'UTR Promotes the Pathogenesis of Urothelial Carcinoma of the Bladder.

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recommendations! Published in 2018 at "Cancer research"

DOI: 10.1158/0008-5472.can-18-0822

Abstract: Shortening of the 3' untranslated regions (3'UTR) of mRNA is an important mechanism for oncogene activation. However, 3'UTR alteration events, their pathologic functions, and underlying mechanisms in human urothelial carcinoma of the bladder (UCB) are… read more here.

Keywords: cstf2; cstf2 induced; isoform; urothelial carcinoma ... See more keywords

The role of CSTF2 in gastric cancer: implications for therapy.

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recommendations! Published in 2025 at "European journal of medical research"

DOI: 10.1186/s40001-025-03570-8

Abstract: Gastric cancer is a fatal malignancy that is frequently diagnosed at an advanced stage worldwide, and current treatments are limited. The RNA-binding protein CSTF2 is associated with the prognosis of many cancers, but the role… read more here.

Keywords: cstf2; role; gastric cancer; cell ... See more keywords

CSTF2 Promotes Hepatocarcinogenesis and Hepatocellular Carcinoma Progression via Aerobic Glycolysis

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recommendations! Published in 2022 at "Frontiers in Oncology"

DOI: 10.3389/fonc.2022.897804

Abstract: Background The shortening of 3’ untranslated regions (3’UTRs) of messenger RNAs(mRNAs) by alternative polyadenylation (APA) is an important mechanism for oncogene activation. Cleavage stimulation factor 2 (CSTF2), an important regulator of APA, has been reported… read more here.

Keywords: cstf2 knockout; function; hcc; cstf2 ... See more keywords