FMRP activity and control of Csw/SHP2 translation regulate MAPK-dependent synaptic transmission
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DOI: 10.1371/journal.pbio.3001969
Abstract: Noonan syndrome (NS) and NS with multiple lentigines (NSML) cognitive dysfunction are linked to SH2 domain-containing protein tyrosine phosphatase-2 (SHP2) gain-of-function (GoF) and loss-of-function (LoF), respectively. In Drosophila disease models, we find both SHP2 mutations… read more here.
Keywords: csw; csw shp2; transmission; activity ... See more keywords