Comparison of Survival Outcomes Among Human Papillomavirus–Negative cT1-2 N1-2b Patients With Oropharyngeal Squamous Cell Cancer Treated With Upfront Surgery vs Definitive Chemoradiation Therapy: An Observational Study
Sign Up to like & getrecommendations! Published in 2017 at "JAMA Oncology"
DOI: 10.1001/jamaoncol.2016.5769
Abstract: Importance Human papillomavirus (HPV)-negative oropharyngeal squamous cell carcinoma (OPSCC) has shown resistance to conventional concurrent chemoradiation (CRT) therapy and carries a relatively poor prognosis in comparison with HPV-positive disease, with decreased locoregional control and overall… read more here.
Keywords: surgery; observational study; ct1; therapy ... See more keywords
Response to letter: Multiparametric magnetic resonance imaging in patients with nonalcoholic fatty liver disease
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Magnetic Resonance Imaging"
DOI: 10.1002/jmri.27510
Abstract: We appreciate the interest in our review article on multiparametric magnetic resonance (MR) methods in patients with nonalcoholic fatty liver disease (NAFLD) and value the authors’ letter expressing their concern that, based on the currently… read more here.
Keywords: fibrosis; magnetic resonance; disease; liver ... See more keywords
Targeting the tight junction protein, zonula occludens-1, with the connexin43 mimetic peptide, αCT1, reduces VEGF-dependent RPE pathophysiology
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Medicine"
DOI: 10.1007/s00109-017-1506-8
Abstract: A critical target tissue in age-related macular degeneration (AMD) is the retinal pigment epithelium (RPE), which forms the outer blood-retina barrier (BRB). RPE-barrier dysfunction might result from attenuation/disruption of intercellular tight junctions. Zonula occludens-1 (ZO-1)… read more here.
Keywords: connexin43 mimetic; zonula occludens; ct1; rpe pathophysiology ... See more keywords
Quantitative magnetic resonance imaging to aid clinical decision making in autoimmune hepatitis
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DOI: 10.1016/j.eclinm.2022.101325
Abstract: Summary Background In autoimmune hepatitis (AIH), clinical practice and treatment guidelines frequently diverge as a reflection of disease heterogeneity and challenges in achieving standardised care. We sought to explore the utility of multiparametric (mp) MR… read more here.
Keywords: decision; decision making; autoimmune hepatitis; ct1 ... See more keywords
Non-invasive assessment of portal hypertension by multi-parametric magnetic resonance imaging of the spleen: A proof of concept study
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DOI: 10.1371/journal.pone.0221066
Abstract: Background and aims Non-invasive assessment of portal hypertension is an area of unmet need. This proof of concept study aimed to evaluate the diagnostic accuracy of a multi-parametric magnetic resonance technique in the assessment of… read more here.
Keywords: invasive assessment; assessment portal; non invasive; ct1 ... See more keywords
Chemoradiation as a nonsurgical treatment option for early-stage esophageal cancers: a retrospective cohort study.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of thoracic disease"
DOI: 10.21037/jtd-20-1187
Abstract: Background Complete tumor removal via esophagectomy or endoscopic excision has been associated with the greatest survival in early-stage esophageal cancer. However, patient health, anatomy, or goals of care may render patients ineligible for excision or… read more here.
Keywords: stage esophageal; ct1; early stage; cancer ... See more keywords
The Cx43 Carboxyl-Terminal Mimetic Peptide αCT1 Protects Endothelial Barrier Function in a ZO1 Binding-Competent Manner
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DOI: 10.3390/biom11081192
Abstract: The Cx43 carboxyl-terminus (CT) mimetic peptide, αCT1, originally designed to bind to Zonula Occludens 1 (ZO1) and thereby inhibit Cx43/ZO1 interaction, was used as a tool to probe the role of Cx43/ZO1 association in regulation… read more here.
Keywords: cx43; ct1; barrier function; zo1 ... See more keywords