Transcriptional downregulation of miR‐127‐3p by CTCF promotes prostate cancer bone metastasis by targeting PSMB5
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13624
Abstract: Prostate cancer (PCa) is one of the most common cancers in males and particularly tends to metastasize to bone. Currently, metastatic bone disease is incurable, and new therapies need to be developed. Our study aims… read more here.
Keywords: ctcf; bone; pca; bone metastasis ... See more keywords
Mitotic phosphorylation of CCCTC‐binding factor (CTCF) reduces its DNA binding activity
Sign Up to like & getrecommendations! Published in 2017 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12189
Abstract: During mitosis, higher order chromatin structures are disrupted and chromosomes are condensed to achieve accurate chromosome segregation. CCCTC‐binding factor (CTCF) is a highly conserved and ubiquitously expressed C2H2‐type zinc finger protein which is considered to… read more here.
Keywords: mitosis; ctcf; dna binding; binding activity ... See more keywords
Mutational analysis identifies functional Rap1, Su(Hw), and CTCF insulator sites in Arabidopsis thaliana.
Sign Up to like & getrecommendations! Published in 2020 at "Plant cell reports"
DOI: 10.1007/s00299-020-02601-4
Abstract: KEY MESSAGE Genetic analysis identifies multiple, potential protein binding sites important for insulator function in Arabidopsis thaliana: Rap1 site in UASrpg, Su(Hw) site in UASrpg, and CTCF site in BEAD1c. Three non-plant insulators UASrpg, BEAD1c,… read more here.
Keywords: analysis identifies; arabidopsis thaliana; site; rap1 ... See more keywords
The ChAHP Complex Counteracts Chromatin Looping at CTCF Sites that Emerged from SINE Expansions in Mouse
Sign Up to like & getrecommendations! Published in 2019 at "Cell"
DOI: 10.1016/j.cell.2019.08.007
Abstract: CCCTC-binding factor (CTCF) and cohesin are key players in three-dimensional chromatin organization. The topologically associating domains (TADs) demarcated by CTCF are remarkably well conserved between species, although genome-wide CTCF binding has diverged substantially following transposon-mediated… read more here.
Keywords: emerged sine; sites emerged; sine expansions; chahp complex ... See more keywords
CTCF functions as an insulator for somatic genes and a chromatin remodeler for pluripotency genes during reprogramming.
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.1016/j.celrep.2022.110626
Abstract: CTCF mediates chromatin insulation and long-distance enhancer-promoter (EP) interactions; however, little is known about how these regulatory functions are partitioned among target genes in key biological processes. Here, we show that Ctcf expression is progressively… read more here.
Keywords: ctcf; ctcf functions; pluripotency; chromatin remodeler ... See more keywords
CTCF knockout reveals an essential role for this protein during the zebrafish development
Sign Up to like & getrecommendations! Published in 2018 at "Mechanisms of Development"
DOI: 10.1016/j.mod.2018.04.006
Abstract: Chromatin regulation and organization are essential processes that regulate gene activity. The CCCTC-binding factor (CTCF) is a protein with different and important molecular functions related with chromatin dynamics. It is conserved since invertebrates to vertebrates,… read more here.
Keywords: protein; zebrafish development; role; ctcf ... See more keywords
Genome Organization: Cohesin on the Move.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular cell"
DOI: 10.1016/j.molcel.2017.05.002
Abstract: Folding of mammalian genomes into spatial domains is thought to depend on cohesin and CTCF proteins. Busslinger et al. (2017) reveal that transcription moves cohesin along DNA to CTCF-binding sites, providing insights into how cohesin and CTCF… read more here.
Keywords: organization cohesin; cohesin; cohesin move; ctcf ... See more keywords
Curaxin-Induced DNA Topology Alterations Trigger the Distinct Binding Response of CTCF and FACT at the Single-Molecule Level.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemistry"
DOI: 10.1021/acs.biochem.1c00014
Abstract: The candidate anticancer drug curaxins can insert into DNA base pairs and efficiently inhibit the growth of various cancers. However, how curaxins alter the genomic DNA structure and affect the DNA binding property of key… read more here.
Keywords: single molecule; dna; fact; topology ... See more keywords
Cohesin is positioned in mammalian genomes by transcription, CTCF and Wapl.
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/nature22063
Abstract: Mammalian genomes are spatially organized by CCCTC-binding factor (CTCF) and cohesin into chromatin loops and topologically associated domains, which have important roles in gene regulation and recombination. By binding to specific sequences, CTCF defines contact… read more here.
Keywords: mammalian genomes; cohesin; transcription ctcf; ctcf ... See more keywords
CTCF genetic alterations in endometrial carcinoma are pro-tumorigenic
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2017.25
Abstract: CTCF is a haploinsufficient tumour suppressor gene with diverse normal functions in genome structure and gene regulation. However the mechanism by which CTCF haploinsufficiency contributes to cancer development is not well understood. CTCF is frequently… read more here.
Keywords: pro tumorigenic; ctcf genetic; ctcf haploinsufficiency; genetic alterations ... See more keywords
A TAD boundary is preserved upon deletion of the CTCF-rich Firre locus
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-03614-0
Abstract: The binding of the transcriptional regulator CTCF to the genome has been implicated in the formation of topologically associated domains (TADs). However, the general mechanisms of folding the genome into TADs are not fully understood.… read more here.
Keywords: ctcf rich; formation; deletion; tad boundary ... See more keywords