Contribution of CTCF binding to transcriptional activity at the HOXA locus in NPM1-mutant AML cells
Sign Up to like & getrecommendations! Published in 2020 at "Leukemia"
DOI: 10.1038/s41375-020-0856-3
Abstract: Transcriptional regulation of the HOXA genes is thought to involve CTCF-mediated chromatin loops and the opposing actions of the COMPASS and Polycomb epigenetic complexes. We investigated the role of these mechanisms at the HOXA cluster… read more here.
Keywords: npm1 mutant; hoxa; ctcf binding; hoxa locus ... See more keywords
Mutation hotspots at CTCF binding sites coupled to chromosomal instability in gastrointestinal cancers
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DOI: 10.1038/s41467-018-03828-2
Abstract: Tissue-specific driver mutations in non-coding genomic regions remain undefined for most cancer types. Here, we unbiasedly analyze 212 gastric cancer (GC) whole genomes to identify recurrently mutated non-coding regions in GC. Applying comprehensive statistical approaches… read more here.
Keywords: ctcf binding; chromosomal instability; binding sites; non coding ... See more keywords
Characterization of the ICCE Repeat in Mammals Reveals an Evolutionary Relationship with the DXZ4 Macrosatellite through Conserved CTCF Binding Motifs
Sign Up to like & getrecommendations! Published in 2018 at "Genome Biology and Evolution"
DOI: 10.1093/gbe/evy176
Abstract: Abstract Appreciation is growing for how chromosomes are organized in three-dimensional space at interphase. Microscopic and high throughput sequence-based studies have established that the mammalian inactive X chromosome (Xi) adopts an alternate conformation relative to… read more here.
Keywords: icce repeat; repeat; ctcf binding; characterization icce ... See more keywords
Histone variant H2A.Z regulates nucleosome unwrapping and CTCF binding in mouse ES cells
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa360
Abstract: Abstract Nucleosome is the basic structural unit of chromatin, and its dynamics plays critical roles in the regulation of genome functions. However, how the nucleosome structure is regulated by histone variants in vivo is still… read more here.
Keywords: variant h2a; h2a nucleosomes; ctcf binding; h2a ... See more keywords
Reactivation of Epstein-Barr Virus from Latency Involves Increased RNA Polymerase Activity at CTCF Binding Sites on the Viral Genome
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DOI: 10.1128/jvi.01894-22
Abstract: The ability of EBV to switch between latent and lytic infection is key to its long-term persistence in memory B cells, and its ability to persist in proliferating cells is strongly linked to oncogenesis. During… read more here.
Keywords: ctcf binding; reactivation; latency; activity ... See more keywords
Functional signatures of evolutionarily young CTCF binding sites
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DOI: 10.1186/s12915-020-00863-8
Abstract: Background The introduction of novel CTCF binding sites in gene regulatory regions in the rodent lineage is partly the effect of transposable element expansion, particularly in the murine lineage. The exact mechanism and functional impact… read more here.
Keywords: novel ctcf; functional signatures; ctcf binding; binding sites ... See more keywords
Spatial patterns of CTCF sites define the anatomy of TADs and their boundaries
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DOI: 10.1186/s13059-020-02108-x
Abstract: Topologically associating domains (TADs) are genomic regions of self-interaction. Additionally, it is known that TAD boundaries are enriched in CTCF binding sites. In turn, CTCF sites are known to be asymmetric, whereby the convergent configuration… read more here.
Keywords: anatomy; ctcf binding; ctcf site; ctcf sites ... See more keywords
Differential CTCF binding in motor neurons and lymphocytes
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DOI: 10.12688/f1000research.53484.1
Abstract: Background: Diversity is critical to lymphocyte roles in the immune system and to neurons, which form complex network structures in the brain. Emerging evidence suggests that an increasing number of molecules associated with the immune… read more here.
Keywords: motor neurons; ctcf binding; neurons lymphocytes; ctcf ... See more keywords
Butyrate Induces Modifications of the CTCF-Binding Landscape in Cattle Cells
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DOI: 10.3390/biom12091177
Abstract: Butyrate is produced in the rumen from microbial fermentation and is related to several functions, including cell differentiation and proliferation. Butyrate supplementation in calves can accelerate rumen development. DNA-protein interactions, such as the CCCTC-binding factor… read more here.
Keywords: dcbs; rumen development; ctcf binding; butyrate ... See more keywords