Contribution of CTCF binding to transcriptional activity at the HOXA locus in NPM1-mutant AML cells
Sign Up to like & getrecommendations! Published in 2020 at "Leukemia"
DOI: 10.1038/s41375-020-0856-3
Abstract: Transcriptional regulation of the HOXA genes is thought to involve CTCF-mediated chromatin loops and the opposing actions of the COMPASS and Polycomb epigenetic complexes. We investigated the role of these mechanisms at the HOXA cluster… read more here.
Keywords: npm1 mutant; hoxa; ctcf binding; hoxa locus ... See more keywords
Mutation hotspots at CTCF binding sites coupled to chromosomal instability in gastrointestinal cancers
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DOI: 10.1038/s41467-018-03828-2
Abstract: Tissue-specific driver mutations in non-coding genomic regions remain undefined for most cancer types. Here, we unbiasedly analyze 212 gastric cancer (GC) whole genomes to identify recurrently mutated non-coding regions in GC. Applying comprehensive statistical approaches… read more here.
Keywords: ctcf binding; chromosomal instability; binding sites; non coding ... See more keywords
Interplay between CTCF-binding and CTCF-lacking regulatory elements in generating an architectural stripe at the Igh locus
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-57373-w
Abstract: Three-dimensional genome organization orchestrates recombination and transcription of immunoglobulin heavy chain (Igh) genes. The structure of wild-type (WT) alleles includes a prominent architectural stripe that extends from a cluster of CTCF binding elements at the… read more here.
Keywords: regulatory elements; ctcf binding; architectural stripe; ctcf ... See more keywords
Site Specific and Orientation Dependent CTCF Binding Determines VDJ Recombination at Murine Tcrb Locus
Sign Up to like & getrecommendations! Published in 2025 at "Molecular and Cellular Biology"
DOI: 10.1080/10985549.2025.2553650
Abstract: Abstract CTCF is a multifunctional protein that mediates long-range cis-DNA interactions in mammalian genomes. Chromatin architecture governs spatial and functional interactions of gene regulatory elements at various loci and is impacted by the ability of… read more here.
Keywords: ctcf binding; recombination; vdj recombination; tcrb locus ... See more keywords
Characterization of the ICCE Repeat in Mammals Reveals an Evolutionary Relationship with the DXZ4 Macrosatellite through Conserved CTCF Binding Motifs
Sign Up to like & getrecommendations! Published in 2018 at "Genome Biology and Evolution"
DOI: 10.1093/gbe/evy176
Abstract: Abstract Appreciation is growing for how chromosomes are organized in three-dimensional space at interphase. Microscopic and high throughput sequence-based studies have established that the mammalian inactive X chromosome (Xi) adopts an alternate conformation relative to… read more here.
Keywords: icce repeat; repeat; ctcf binding; characterization icce ... See more keywords
Histone variant H2A.Z regulates nucleosome unwrapping and CTCF binding in mouse ES cells
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa360
Abstract: Abstract Nucleosome is the basic structural unit of chromatin, and its dynamics plays critical roles in the regulation of genome functions. However, how the nucleosome structure is regulated by histone variants in vivo is still… read more here.
Keywords: variant h2a; h2a nucleosomes; ctcf binding; h2a ... See more keywords
DARDN: A Deep-Learning Approach for CTCF Binding Sequence Classification and Oncogenic Regulatory Feature Discovery
Sign Up to like & getrecommendations! Published in 2024 at "Genes"
DOI: 10.1101/2023.11.17.567502
Abstract: Characterization of gene regulatory mechanisms in cancer is a key task in cancer genomics. CCCTC-binding factor (CTCF), a DNA binding protein, exhibits specific binding patterns in the genome of cancer cells and has a non-canonical… read more here.
Keywords: cancer; ctcf binding; sequence; transcription ... See more keywords
Wnt signaling activation induces CTCF binding and loop formation at cis-regulatory elements of target genes
Sign Up to like & getrecommendations! Published in 2025 at "Genome Research"
DOI: 10.1101/gr.279684.124
Abstract: Wnt signaling plays a pivotal role during development and homeostasis. Upon pathway activation, CTNNB1 (also known as beta-catenin) drives the expression of target genes from regulatory regions bound by TCF/LEF transcription factors. Gene regulation, however,… read more here.
Keywords: wnt signaling; target genes; ctcf binding; activation ... See more keywords
Reactivation of Epstein-Barr Virus from Latency Involves Increased RNA Polymerase Activity at CTCF Binding Sites on the Viral Genome
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.01894-22
Abstract: The ability of EBV to switch between latent and lytic infection is key to its long-term persistence in memory B cells, and its ability to persist in proliferating cells is strongly linked to oncogenesis. During… read more here.
Keywords: ctcf binding; reactivation; latency; activity ... See more keywords
Abstract 2744: Interrogating the functional roles of differential CTCF-binding sites in IDH-mutant gliomas using a novel CRISPR library
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-2744
Abstract: Isocitrate dehydrogenase (IDH) mutations are frequently observed in gliomas, and their mutation status is accepted as a CNS tumor classification marker. IDHs are enzymes that convert isocitrate into alpha-ketoglutarate (α-KG). Mutations in IDHs cause neomorphic… read more here.
Keywords: mutant gliomas; ctcf binding; ctcf; binding sites ... See more keywords
Functional signatures of evolutionarily young CTCF binding sites
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DOI: 10.1186/s12915-020-00863-8
Abstract: Background The introduction of novel CTCF binding sites in gene regulatory regions in the rodent lineage is partly the effect of transposable element expansion, particularly in the murine lineage. The exact mechanism and functional impact… read more here.
Keywords: novel ctcf; functional signatures; ctcf binding; binding sites ... See more keywords