Principles of Chromosome Architecture Revealed by Hi-C.
Sign Up to like & getrecommendations! Published in 2018 at "Trends in biochemical sciences"
DOI: 10.1016/j.tibs.2018.03.006
Abstract: Chromosomes are folded and compacted in interphase nuclei, but the molecular basis of this folding is poorly understood. Chromosome conformation capture methods, such as Hi-C, combine chemical crosslinking of chromatin with fragmentation, DNA ligation, and… read more here.
Keywords: dna; cohesin; ctcf cohesin; principles chromosome ... See more keywords
Implications of Dosage Deficiencies in CTCF and Cohesin on Genome Organization, Gene Expression, and Human Neurodevelopment
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DOI: 10.3390/genes13040583
Abstract: Properly organizing DNA within the nucleus is critical to ensure normal downstream nuclear functions. CTCF and cohesin act as major architectural proteins, working in concert to generate thousands of high-intensity chromatin loops. Due to their… read more here.
Keywords: ctcf cohesin; deficiencies ctcf; gene expression;