CCR4-IL2 bispecific immunotoxin is more effective than brentuximab for targeted therapy of cutaneous T-cell lymphoma in a mouse CTCL model.
Sign Up to like & getrecommendations! Published in 2023 at "FEBS open bio"
DOI: 10.1002/2211-5463.13625
Abstract: Cutaneous T-cell lymphoma (CTCL) encompasses two main subtypes: mycosis fungoides and Sezary syndrome. Global response rates for the systemic treatment of mycosis fungoides and Sezary syndrome are approximately 30% and none of these treatments are… read more here.
Keywords: ctcl; ccr4 il2; mouse; model ... See more keywords
The “m6A writer” METTL3 and the “m6A reader” IGF2BP2 regulate cutaneous T‐cell lymphomas progression via CDKN2A
Sign Up to like & getrecommendations! Published in 2022 at "Hematological Oncology"
DOI: 10.1002/hon.3005
Abstract: It has been established that Cutaneous T‐Cell lymphomas (CTCL) are caused by the monoclonal proliferation of T lymphocytes in the skin. This heterogeneous group of diseases represents a significant source of distress to patients since… read more here.
Keywords: progression; ctcl; cell lymphomas; m6a ... See more keywords
Molecular profiling of TOX-deficient neoplastic cells in cutaneous T cell lymphoma
Sign Up to like & getrecommendations! Published in 2019 at "Archives of Dermatological Research"
DOI: 10.1007/s00403-019-02000-0
Abstract: Cutaneous T cell lymphoma (CTCL) is a rare but potentially devastating primary cutaneous lymphoma. CTCL is characterized by localization of neoplastic T lymphocytes to the skin, with mycosis fungoides (MF) and its leukemic form, Sézary… read more here.
Keywords: cutaneous cell; ctcl; gene; cell ... See more keywords
Compartiments immuns malins, T bénins conventionnels et régulateurs chez 36 patients traités par mogamulizumab pour CTCL avancé
Sign Up to like & getrecommendations! Published in 2019 at "Annales De Dermatologie Et De Venereologie"
DOI: 10.1016/j.annder.2019.09.142
Abstract: Introduction Le mogamulizumab, anticorps monoclonal anti-CCR4, induit, chez les patients atteints de lymphome T cutane (CTCL) refractaires a au moins un traitement systemique, une survie sans progression superieure au vorinostat. Il provoque une depletion des… read more here.
Keywords: par mogamulizumab; ctcl; les patients; ont ete ... See more keywords
Novel cell adhesion/migration pathways are predictive markers of HDAC inhibitor resistance in cutaneous T cell lymphoma
Sign Up to like & getrecommendations! Published in 2019 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2019.07.053
Abstract: Background Treatment for Cutaneous T Cell Lymphoma (CTCL) is generally not curative. Therefore, selecting therapy that is effective and tolerable is critical to clinical decision-making. Histone deacetylase inhibitors (HDACi), epigenetic modifier drugs, are commonly used… read more here.
Keywords: cutaneous cell; acetylation; treatment; ctcl ... See more keywords
ITK inhibition for the targeted treatment of CTCL.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of dermatological science"
DOI: 10.1016/j.jdermsci.2017.04.001
Abstract: Cutaneous T cell lymphomas (CTCLs) comprise a heterogeneous group of uncommon non-Hodgkin lymphomas with primary manifestations in the skin [1]. Though CTCL treatment strategies are rapidly evolving, novel CTCL-targeted therapies are still needed, especially for… read more here.
Keywords: itk inhibition; treatment; ctcl; fig ... See more keywords
PAK1 overexpression promotes cell proliferation in cutaneous T cell lymphoma via suppression of PUMA and p21.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of dermatological science"
DOI: 10.1016/j.jdermsci.2017.11.019
Abstract: BACKGROUND Cutaneous T cell lymphoma (CTCL) comprises a heterogeneous group of skin-homing T cell tumors. The small guanosine triphosphate effector p21-activated kinase 1 (PAK1) plays an important role in many fundamental cellular functions, including cell… read more here.
Keywords: ctcl; proliferation; expression; p21 ... See more keywords
Molecular pathogenesis of Cutaneous T cell Lymphoma: Role of chemokines, cytokines, and dysregulated signaling pathways.
Sign Up to like & getrecommendations! Published in 2021 at "Seminars in cancer biology"
DOI: 10.1016/j.semcancer.2021.12.003
Abstract: Cutaneous T cell lymphomas (CTCLs) are a heterogeneous group of lymphoproliferative neoplasms, which exhibit a wide spectrum of immune-phenotypical, clinical, and histopathological features. The biology of CTCL is complex and remains elusive. In recent years,… read more here.
Keywords: ctcl; cutaneous cell; role; cell ... See more keywords
Screening of ferrocenyl–phosphines identifies a gold-coordinated derivative as a novel anticancer agent for hematological malignancies
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DOI: 10.1039/c8ra05224g
Abstract: The development of new organometallic compounds as anticancer agents is currently an active area of research. Here, we report the design, synthesis and characterization of a panel of 10 new ferrocenyl–phosphine derivatives (FD1–FD10) and the… read more here.
Keywords: screening ferrocenyl; cell; ctcl; ferrocenyl phosphine ... See more keywords
Health state utilities associated with caring for an individual with cutaneous T-cell lymphoma (CTCL)
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DOI: 10.1080/13696998.2020.1793764
Abstract: Abstract Aim Cutaneous T-cell Lymphoma (CTCL) is a rare form of non-Hodgkin lymphoma characterized by skin lesions, which can negatively impact the quality of life of both patients and their caregivers. The Decision Support Unit… read more here.
Keywords: health state; treatment; ctcl; health ... See more keywords
Novel therapeutic approaches for cutaneous T cell lymphomas
Sign Up to like & getrecommendations! Published in 2021 at "Expert Review of Clinical Immunology"
DOI: 10.1080/1744666x.2021.1919085
Abstract: ABSTRACT Introduction: Cutaneous T-cell lymphoma (CTCL) is a rare non-Hodgkin’s lymphoma, characterized by malignant T cells infiltrating the skin. CTCL exhibits vast heterogeneity which complicates diagnosis and therapeutic strategies. Current CTCL treatment includes skin-directed therapies… read more here.
Keywords: novel therapeutic; treatment; cutaneous cell; ctcl ... See more keywords