JAK2 Fusions in Adult Patients With Mycosis Fungoides and CD30 Lymphoproliferative Disorders.
Sign Up to like & getrecommendations! Published in 2025 at "JAMA dermatology"
DOI: 10.1001/jamadermatol.2025.4688
Abstract: Importance Janus kinase 2 (JAK2) gene fusions characterize cytotoxic cutaneous T-cell lymphoma (CTCL) including primary cutaneous CD8-positive aggressive epidermotropic cytotoxic T-cell lymphoma (pcAETCL). The identification of these fusions is rarely reported in indolent CTCL. Objective… read more here.
Keywords: jak2 fusions; lymphoproliferative disorders; mycosis fungoides; fungoides cd30 ... See more keywords
CCR4-IL2 bispecific immunotoxin is more effective than brentuximab for targeted therapy of cutaneous T-cell lymphoma in a mouse CTCL model.
Sign Up to like & getrecommendations! Published in 2023 at "FEBS open bio"
DOI: 10.1002/2211-5463.13625
Abstract: Cutaneous T-cell lymphoma (CTCL) encompasses two main subtypes: mycosis fungoides and Sezary syndrome. Global response rates for the systemic treatment of mycosis fungoides and Sezary syndrome are approximately 30% and none of these treatments are… read more here.
Keywords: ctcl; ccr4 il2; mouse; model ... See more keywords
The “m6A writer” METTL3 and the “m6A reader” IGF2BP2 regulate cutaneous T‐cell lymphomas progression via CDKN2A
Sign Up to like & getrecommendations! Published in 2022 at "Hematological Oncology"
DOI: 10.1002/hon.3005
Abstract: It has been established that Cutaneous T‐Cell lymphomas (CTCL) are caused by the monoclonal proliferation of T lymphocytes in the skin. This heterogeneous group of diseases represents a significant source of distress to patients since… read more here.
Keywords: progression; ctcl; cell lymphomas; m6a ... See more keywords
Molecular profiling of TOX-deficient neoplastic cells in cutaneous T cell lymphoma
Sign Up to like & getrecommendations! Published in 2019 at "Archives of Dermatological Research"
DOI: 10.1007/s00403-019-02000-0
Abstract: Cutaneous T cell lymphoma (CTCL) is a rare but potentially devastating primary cutaneous lymphoma. CTCL is characterized by localization of neoplastic T lymphocytes to the skin, with mycosis fungoides (MF) and its leukemic form, Sézary… read more here.
Keywords: cutaneous cell; ctcl; gene; cell ... See more keywords
Compartiments immuns malins, T bénins conventionnels et régulateurs chez 36 patients traités par mogamulizumab pour CTCL avancé
Sign Up to like & getrecommendations! Published in 2019 at "Annales De Dermatologie Et De Venereologie"
DOI: 10.1016/j.annder.2019.09.142
Abstract: Introduction Le mogamulizumab, anticorps monoclonal anti-CCR4, induit, chez les patients atteints de lymphome T cutane (CTCL) refractaires a au moins un traitement systemique, une survie sans progression superieure au vorinostat. Il provoque une depletion des… read more here.
Keywords: par mogamulizumab; ctcl; les patients; ont ete ... See more keywords
Novel cell adhesion/migration pathways are predictive markers of HDAC inhibitor resistance in cutaneous T cell lymphoma
Sign Up to like & getrecommendations! Published in 2019 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2019.07.053
Abstract: Background Treatment for Cutaneous T Cell Lymphoma (CTCL) is generally not curative. Therefore, selecting therapy that is effective and tolerable is critical to clinical decision-making. Histone deacetylase inhibitors (HDACi), epigenetic modifier drugs, are commonly used… read more here.
Keywords: cutaneous cell; acetylation; treatment; ctcl ... See more keywords
ITK inhibition for the targeted treatment of CTCL.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of dermatological science"
DOI: 10.1016/j.jdermsci.2017.04.001
Abstract: Cutaneous T cell lymphomas (CTCLs) comprise a heterogeneous group of uncommon non-Hodgkin lymphomas with primary manifestations in the skin [1]. Though CTCL treatment strategies are rapidly evolving, novel CTCL-targeted therapies are still needed, especially for… read more here.
Keywords: itk inhibition; treatment; ctcl; fig ... See more keywords
PAK1 overexpression promotes cell proliferation in cutaneous T cell lymphoma via suppression of PUMA and p21.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of dermatological science"
DOI: 10.1016/j.jdermsci.2017.11.019
Abstract: BACKGROUND Cutaneous T cell lymphoma (CTCL) comprises a heterogeneous group of skin-homing T cell tumors. The small guanosine triphosphate effector p21-activated kinase 1 (PAK1) plays an important role in many fundamental cellular functions, including cell… read more here.
Keywords: ctcl; proliferation; expression; p21 ... See more keywords
Molecular pathogenesis of Cutaneous T cell Lymphoma: Role of chemokines, cytokines, and dysregulated signaling pathways.
Sign Up to like & getrecommendations! Published in 2021 at "Seminars in cancer biology"
DOI: 10.1016/j.semcancer.2021.12.003
Abstract: Cutaneous T cell lymphomas (CTCLs) are a heterogeneous group of lymphoproliferative neoplasms, which exhibit a wide spectrum of immune-phenotypical, clinical, and histopathological features. The biology of CTCL is complex and remains elusive. In recent years,… read more here.
Keywords: ctcl; cutaneous cell; role; cell ... See more keywords
CDK9 recruits HUWE1 to degrade RARα and offers therapeutic opportunities for cutaneous T-cell lymphoma
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-54354-3
Abstract: Cutaneous T-cell lymphoma (CTCL) is a heterogeneous non-Hodgkin lymphoma originating in the skin and invading the systemic hematopoietic system. Current treatments, including chemotherapy and monoclonal antibodies yielded limited responses with high incidence of side effects,… read more here.
Keywords: cdk9; cell lymphoma; cutaneous cell; cell ... See more keywords
A novel knockout mouse model to assess the impact of one-copy loss of Hnrnpk in CD4 + T cells in chronically inflamed skin as a prelude to CTCL
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-98640-6
Abstract: Cutaneous T-cell lymphomas (CTCLs), particularly Mycosis fungoides (MF), frequently exhibit deletions and reduced expression of HNRNPK in CD4 + T cells. To enable in vivo studies, we developed a conditional Hnrnpk knockout mouse that thrives, facilitating the… read more here.
Keywords: cd4 cells; hnrnpk; knockout mouse; hnrnpk cd4 ... See more keywords