Circulating tumor DNA changes for early monitoring of anti-PD1 immunotherapy: a proof-of-concept study
Sign Up to like & getrecommendations! Published in 2017 at "Annals of Oncology"
DOI: 10.1093/annonc/mdx212
Abstract: Background Recent clinical results support the use of new immune checkpoint blockers (ICB), such as anti-PD-1 (e.g. nivolumab and pembrolizumab) and anti-PD-L1 antibodies. Radiological evaluation of ICB efficacy during therapy is challenging due to tumor… read more here.
Keywords: study; ctdna levels; circulating tumor; tumor dna ... See more keywords
PO-493 ctDNA profiles of metastatic melanoma patients under therapy
Sign Up to like & getrecommendations! Published in 2018 at "ESMO Open"
DOI: 10.1136/esmoopen-2018-eacr25.995
Abstract: Introduction In precision oncology it is a great interest to develop novel disease and therapy monitoring technologies that are non-invasive and highly sensitive. Specifically, our project aims to establish blood-based assays that allow ‘real-time’ monitoring… read more here.
Keywords: ctdna; disease; ctdna levels; melanoma patients ... See more keywords
Quantification of Translocation-Specific ctDNA Provides an Integrating Parameter for Early Assessment of Treatment Response and Risk Stratification in Ewing Sarcoma
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-21-1324
Abstract: Purpose: We evaluated the predictive and prognostic value of circulating tumor DNA (ctDNA) in patients with Ewing sarcoma (EWS) treated in the EWING2008 trial. Experimental Design: Plasma samples from 102 patients with EWS enrolled in… read more here.
Keywords: ctdna levels; response; ctdna; ewing sarcoma ... See more keywords
Abstract LB289: Longitudinal ctDNA levels and clinical outcomes of first-line (1L) tislelizumab (TIS) + chemotherapy (chemo) treatment for advanced non-small cell lung cancer (NSCLC) in the RATIONALE-304 and 307 studies
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-lb289
Abstract: Background: The role of circulating tumor DNA (ctDNA) in monitoring response to immunotherapy in NSCLC is unconfirmed. This is a retrospective analysis of association between longitudinal ctDNA levels and clinical outcomes in 1L TIS (anti-PD-1)… read more here.
Keywords: ctdna; pfs; rationale 304; ctdna levels ... See more keywords
Clinical Applications of Circulating Tumor DNA in the Diagnosis and Prognostic Stratification of Mantle Cell Lymphoma
Sign Up to like & getrecommendations! Published in 2024 at "Blood"
DOI: 10.1182/blood-2024-201575
Abstract: Background: Mantle cell lymphoma (MCL) is characterized by significant biological and clinical heterogeneity, necessitating the identification of prognostic biomarkers to guide its management. Circulating tumor DNA (ctDNA) has emerged as an innovative diagnostic and prognostic… read more here.
Keywords: plasma ctdna; treatment; ctdna levels; mutation ... See more keywords
Circulating Tumor DNA Predicts Time to First Treatment in Previously Untreated Follicular Lymphoma: Analysis from a Prospective Clonal Evolution Study
Sign Up to like & getrecommendations! Published in 2024 at "Blood"
DOI: 10.1182/blood-2024-201711
Abstract: Background:Follicular lymphoma (FL) shows marked heterogeneity in clinical course including spontaneous regression and histologic transformation (HT). Watchful waiting (W&W) is routinely employed, but monitoring is not standardized. A subset of pts require treatment early after… read more here.
Keywords: treatment; ctdna levels; baseline ctdna; baseline ... See more keywords
Early Assessment of Chemotherapy Response in Advanced Non-Small Cell Lung Cancer with Circulating Tumor DNA
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14102479
Abstract: Simple Summary An early assessment of response to treatment is crucial to informing appropriate therapeutic management. Using a plasma-only strategy, we measured changes in circulating tumor DNA (ctDNA) levels after one or two cycles of… read more here.
Keywords: lung cancer; early assessment; treatment; ctdna levels ... See more keywords