Human pregnancy levels of estrogen and progesterone contribute to humoral immunity by activating TFH/B cell axis
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DOI: 10.1002/eji.202048658
Abstract: Circulating TFH (cTFH) cells express CXCR5, PD‐1, and, when activated, ICOS, and release IL‐21. According to the production of IFN‐γ, IL‐4, and IL‐17 and expression of FoxP3, these cells are also classified as cTFH1, cTFH2,… read more here.
Keywords: pregnancy; ctfh; tfh cell; humoral immunity ... See more keywords
Clonal composition and persistence of antigen‐specific circulating T follicular helper cells
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DOI: 10.1002/eji.202250190
Abstract: T follicular helper (TFH) cells play an essential role in promoting B cell responses and antibody affinity maturation in germinal centers (GC). A subset of memory CD4+ T cells expressing the chemokine receptor CXCR5 has… read more here.
Keywords: ctfh; ctfh cells; follicular helper; ctfh non ... See more keywords
Persistent expansion and Th1-like skewing of HIV-specific circulating T follicular helper cells during antiretroviral therapy
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DOI: 10.1016/j.ebiom.2020.102727
Abstract: Background Untreated HIV infection leads to alterations in HIV-specific CD4+ T cells including increased expression of co-inhibitory receptors (IRs) and skewing toward a T follicular helper cell (Tfh) signature. However, which changes are maintained after… read more here.
Keywords: antiretroviral therapy; ctfh; hiv; th1 ... See more keywords
Circulatory follicular helper T lymphocytes associate with lower incidence of CMV infection in kidney transplant recipients
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DOI: 10.1111/ajt.16725
Abstract: Primary infection and/or reactivation of cytomegalovirus (CMV) in kidney transplant recipients (KTR) favor rejection and mortality. T follicular helper cells (TFH) could contribute to protection against CMV. Circulatory TFH (cTFH) were studied pretransplant and early… read more here.
Keywords: cmv infection; kidney transplant; ctfh; transplant recipients ... See more keywords
Abnormal Shift in B Memory Cell Profile Is Associated With the Expansion of Circulating T Follicular Helper Cells via ICOS Signaling During Acute HIV-1 Infection
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DOI: 10.3389/fimmu.2022.837921
Abstract: Interactions between T follicular helper (Tfh) cells and germinal center B cells are essential for the differentiation of B cells and specific antibody responses against HIV-1 infection. However, the extent to which HIV-1 infection affects… read more here.
Keywords: icos; ctfh; infection; memory ... See more keywords