RASSF1A–Hippo pathway link in patients with urothelial carcinoma of bladder: plausible therapeutic target
Sign Up to like & getrecommendations! Published in 2019 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-019-03648-y
Abstract: RASSF1A is a tumor suppressor gene, and its hypermethylation has been observed in cancers. RASSF1A acts as an upstream regulator of Hippo pathway and modulates its function. The aim of this study was to analyze… read more here.
Keywords: rassf1a; ctgf cyr61; rassf1a hippo; hippo pathway ... See more keywords
YAP, CTGF and Cyr61 are overexpressed in tamoxifen-resistant breast cancer and induce transcriptional repression of ERα.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cell science"
DOI: 10.1242/jcs.256503
Abstract: About 70% of breast cancers overexpress estrogen receptor α (ERα, encoded by ESR1). Tamoxifen, a competitive inhibitor of estrogen that binds to ER, has been widely used as a treatment for ER-positive breast cancer. However,… read more here.
Keywords: tamoxifen; ctgf cyr61; breast cancer;