CTHRC1 Knockdown Promotes Inflammatory Responses Partially by p38 MAPK Activation in Human Periodontal Ligament Cells.
Sign Up to like & getrecommendations! Published in 2021 at "Inflammation"
DOI: 10.1007/s10753-021-01461-8
Abstract: Collagen triple helix repeat containing 1 (CTHRC1), a secreted glycoprotein, is widely expressed in many tissues. It has been recently defined as a novel marker for rheumatoid arthritis (RA), a systemic inflammatory disorder. However, the… read more here.
Keywords: p38 mapk; periodontal ligament; cthrc1 knockdown; cthrc1 ... See more keywords
CTHRC1 affects malignant tumor cell behavior and is regulated by miR-30e-5p in human prostate cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.02.098
Abstract: Collagen Triple Helix Repeat Containing 1 (CTHRC1) has been picked out as a cancer-related, secreted glycoprotein that possesses multifaceted functions such as wound repair, the formation of adipose tissue, hepatocytes fibrosis, and bone remodeling. This… read more here.
Keywords: human prostate; cthrc1; mir 30e; prostate cancer ... See more keywords
Inhibition of osteoclast differentiation and collagen antibody-induced arthritis by CTHRC1.
Sign Up to like & getrecommendations! Published in 2017 at "Bone"
DOI: 10.1016/j.bone.2017.01.022
Abstract: Collagen triple helix repeat-containing1 (Cthrc1) has previously been implicated in osteogenic differentiation and positive regulation of bone mass, however, the underlying mechanisms remain unclear. Here we characterized the bone phenotype of a novel Cthrc1 null… read more here.
Keywords: null mice; cthrc1; bone; differentiation ... See more keywords
CTHRC1 expressed in periodontitis and human periodontal fibroblasts exposed to inflammatory stimuli.
Sign Up to like & getrecommendations! Published in 2022 at "Oral diseases"
DOI: 10.1111/odi.14151
Abstract: OBJECTIVES Collagen triple helix repeat containing-1 (CTHRC1) is a glycoprotein that can be secreted extracellularly and is involved in the regulation of collagen matrix in a variety of diseases. The expression level of CTHRC1 in… read more here.
Keywords: expressed periodontitis; expression; periodontitis; cthrc1 expressed ... See more keywords
Collagen triple helix repeat containing-1: a novel biomarker associated with disease activity in Systemic lupus erythematosus
Sign Up to like & getrecommendations! Published in 2018 at "Lupus"
DOI: 10.1177/0961203318804877
Abstract: Objective The objective of this article is to investigate whether the aberrant expression of collagen triple helix repeat containing-1 (CTHRC1) from patients with systemic lupus erythematosus (SLE) could contribute to the pathogenesis of lupus. Methods… read more here.
Keywords: cthrc1; systemic lupus; lupus erythematosus; disease ... See more keywords
Pirfenidone attenuates lung fibrotic fibroblast responses to transforming growth factor-β1
Sign Up to like & getrecommendations! Published in 2019 at "Respiratory Research"
DOI: 10.1186/s12931-019-1093-z
Abstract: BackgroundPirfenidone, an antifibrotic agent used for the treatment of idiopathic pulmonary fibrosis (IPF), functions by inhibiting myofibroblast differentiation, which is involved in transforming growth factor (TGF)-β1-induced IPF pathogenesis. However, unlike normal lung fibroblasts, the relationship… read more here.
Keywords: transforming growth; lung fibroblasts; fibroblast; cthrc1 ... See more keywords
Pan-cancer analysis combined with experiments predicts CTHRC1 as a therapeutic target for human cancers
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Cell International"
DOI: 10.1186/s12935-021-02266-3
Abstract: Background The function of collagen triple helix repeat containing 1 (CTHRC1) as an oncogene has been reported in a growing number of publications. Bioinformatics methods represent a beneficial approach to examine the mechanism and function… read more here.
Keywords: pan cancer; cthrc1; cancer analysis; target ... See more keywords
Collagen triple helix repeat containing 1 (CTHRC1) activates Integrin β3/FAK signaling and promotes metastasis in ovarian cancer
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Ovarian Research"
DOI: 10.1186/s13048-017-0358-8
Abstract: BackgroundMetastasis is the major cause of morbidity and mortality in patients with epithelial ovarian cancer (EOC), however the mechanisms that underline this process are poorly understood. Collagen triple helix repeat containing-1 (CTHRC1) is a 28-kDa… read more here.
Keywords: fak signaling; cthrc1; eoc; integrin fak ... See more keywords
CTHRC1 is a Potential Prognostic Biomarker and Correlated with Macrophage Infiltration in Breast Cancer
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of General Medicine"
DOI: 10.2147/ijgm.s366272
Abstract: Background Tumor immune cell infiltration is closely associated with the occurrence and development of tumors. Collagen triple helix repeats containing 1 (CTHRC1), a regulator of collagen expression and cell migration, is involved in the metastasis… read more here.
Keywords: infiltration; cancer; expression; breast cancer ... See more keywords
Identification and Verification of Potential Biomarkers in Gastric Cancer By Integrated Bioinformatic Analysis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.911740
Abstract: Background: Gastric cancer (GC) is a common cancer with high mortality. This study aimed to identify its differentially expressed genes (DEGs) using bioinformatics methods. Methods: DEGs were screened from four GEO (Gene Expression Omnibus) gene… read more here.
Keywords: prognosis; collagen; analysis; gastric cancer ... See more keywords
CTHRC1 Is a Prognostic Biomarker and Correlated With Immune Infiltrates in Kidney Renal Papillary Cell Carcinoma and Kidney Renal Clear Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.570819
Abstract: Kidney renal clear cell carcinoma (KIRC) and kidney renal papillary cell carcinoma (KIRP) are the most common RCC types. RCC has high immune infiltration levels, and immunotherapy is currently one of the most promising treatments… read more here.
Keywords: cthrc1; kidney renal; cell carcinoma; kirp kirc ... See more keywords