CTHRC1 Attenuates Tendinopathy via Enhancing EGFR/MAPK Signaling Pathway
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202406611
Abstract: Tendinopathy poses a formidable challenge due to the inherent limitations of tendon regenerative capabilities post‐injury. At present, effective curative approaches for tendinopathy are still lacking. Collagen triple helix repeat‐containing 1 (CTHRC1) is an extracellular matrix… read more here.
Keywords: cthrc1; mapk signaling; tendon healing; signaling pathway ... See more keywords
CTHRC1 promotes bone metastasis in prostate cancer
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Cancer"
DOI: 10.1002/ijc.70012
Abstract: Prostate cancer causes a high frequency of bone metastases. The purpose of this study was to identify molecules that regulate prostate cancer bone metastasis as potential therapeutic and/or prognostic targets in prostate cancer, using integrative… read more here.
Keywords: cthrc1; cancer; prostate cancer; bone metastasis ... See more keywords
CTHRC1 Knockdown Promotes Inflammatory Responses Partially by p38 MAPK Activation in Human Periodontal Ligament Cells.
Sign Up to like & getrecommendations! Published in 2021 at "Inflammation"
DOI: 10.1007/s10753-021-01461-8
Abstract: Collagen triple helix repeat containing 1 (CTHRC1), a secreted glycoprotein, is widely expressed in many tissues. It has been recently defined as a novel marker for rheumatoid arthritis (RA), a systemic inflammatory disorder. However, the… read more here.
Keywords: p38 mapk; periodontal ligament; cthrc1 knockdown; cthrc1 ... See more keywords
CTHRC1 affects malignant tumor cell behavior and is regulated by miR-30e-5p in human prostate cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.02.098
Abstract: Collagen Triple Helix Repeat Containing 1 (CTHRC1) has been picked out as a cancer-related, secreted glycoprotein that possesses multifaceted functions such as wound repair, the formation of adipose tissue, hepatocytes fibrosis, and bone remodeling. This… read more here.
Keywords: human prostate; cthrc1; mir 30e; prostate cancer ... See more keywords
Inhibition of osteoclast differentiation and collagen antibody-induced arthritis by CTHRC1.
Sign Up to like & getrecommendations! Published in 2017 at "Bone"
DOI: 10.1016/j.bone.2017.01.022
Abstract: Collagen triple helix repeat-containing1 (Cthrc1) has previously been implicated in osteogenic differentiation and positive regulation of bone mass, however, the underlying mechanisms remain unclear. Here we characterized the bone phenotype of a novel Cthrc1 null… read more here.
Keywords: null mice; cthrc1; bone; differentiation ... See more keywords
CTHRC1 expressed in periodontitis and human periodontal fibroblasts exposed to inflammatory stimuli.
Sign Up to like & getrecommendations! Published in 2022 at "Oral diseases"
DOI: 10.1111/odi.14151
Abstract: OBJECTIVES Collagen triple helix repeat containing-1 (CTHRC1) is a glycoprotein that can be secreted extracellularly and is involved in the regulation of collagen matrix in a variety of diseases. The expression level of CTHRC1 in… read more here.
Keywords: expressed periodontitis; expression; periodontitis; cthrc1 expressed ... See more keywords
Abstract 2914: AI/ML-driven discovery of CTHRC1, collagen triple helix repeat-containing 1, a novel proteoglycan for stroma + tumor targeting and delivery of 4-1BB costimulation
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-2914
Abstract: Background: While checkpoint inhibitors have demonstrated efficacy in a number of solid tumor indications, those with high stromal presence have been difficult to treat with minimal objective responses observed. Phenomic has developed a proprietary machine… read more here.
Keywords: immune activating; cancer; cthrc1; novel proteoglycan ... See more keywords
Collagen triple helix repeat containing-1: a novel biomarker associated with disease activity in Systemic lupus erythematosus
Sign Up to like & getrecommendations! Published in 2018 at "Lupus"
DOI: 10.1177/0961203318804877
Abstract: Objective The objective of this article is to investigate whether the aberrant expression of collagen triple helix repeat containing-1 (CTHRC1) from patients with systemic lupus erythematosus (SLE) could contribute to the pathogenesis of lupus. Methods… read more here.
Keywords: cthrc1; systemic lupus; lupus erythematosus; disease ... See more keywords
Pirfenidone attenuates lung fibrotic fibroblast responses to transforming growth factor-β1
Sign Up to like & getrecommendations! Published in 2019 at "Respiratory Research"
DOI: 10.1186/s12931-019-1093-z
Abstract: BackgroundPirfenidone, an antifibrotic agent used for the treatment of idiopathic pulmonary fibrosis (IPF), functions by inhibiting myofibroblast differentiation, which is involved in transforming growth factor (TGF)-β1-induced IPF pathogenesis. However, unlike normal lung fibroblasts, the relationship… read more here.
Keywords: transforming growth; lung fibroblasts; fibroblast; cthrc1 ... See more keywords
Pan-cancer analysis combined with experiments predicts CTHRC1 as a therapeutic target for human cancers
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Cell International"
DOI: 10.1186/s12935-021-02266-3
Abstract: Background The function of collagen triple helix repeat containing 1 (CTHRC1) as an oncogene has been reported in a growing number of publications. Bioinformatics methods represent a beneficial approach to examine the mechanism and function… read more here.
Keywords: pan cancer; cthrc1; cancer analysis; target ... See more keywords
Collagen triple helix repeat containing 1 (CTHRC1) activates Integrin β3/FAK signaling and promotes metastasis in ovarian cancer
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Ovarian Research"
DOI: 10.1186/s13048-017-0358-8
Abstract: BackgroundMetastasis is the major cause of morbidity and mortality in patients with epithelial ovarian cancer (EOC), however the mechanisms that underline this process are poorly understood. Collagen triple helix repeat containing-1 (CTHRC1) is a 28-kDa… read more here.
Keywords: fak signaling; cthrc1; eoc; integrin fak ... See more keywords