Recombinant MUC1-MBP fusion protein vaccine combined with CpG2006 induces antigen-specific CTL responses through cDC1-mediated cross-priming mainly regulated by type I IFN signaling in mice.
Sign Up to like & getrecommendations! Published in 2022 at "Immunology letters"
DOI: 10.1016/j.imlet.2022.04.002
Abstract: In this study, we explored the initiation and regulation mechanism of antigen-specific CTL responses induced by a novel cancer vaccine containing recombinant human mucin1-maltose-binding protein fusion protein (MUC1-MBP) and CpG2006. First, DC subsets were analyzed… read more here.
Keywords: specific ctl; ifn signaling; type ifn; ctl responses ... See more keywords
P2X receptor agonist enhances tumor-specific CTL responses through CD70 + DC-mediated Th17 induction.
Sign Up to like & getrecommendations! Published in 2020 at "International immunology"
DOI: 10.1093/intimm/dxaa068
Abstract: Extracellular ATP is known to promote Th17 cell differentiation in the intestinal lamina propria by stimulating CD70 +CD11c low dendritic cells (DCs) via P2X receptors (P2XRs). Recent studies have also shown that Th17 cells enhance… read more here.
Keywords: th17 induction; ctl responses; atp; intranasally immunized ... See more keywords
A DNA-Launched Nanoparticle Vaccine Elicits CD8+ T-cell Immunity to Promote In Vivo Tumor Control
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-20-0061
Abstract: DNA nanoparticle vaccination plus electroporation robustly induces CD8+ CTL responses that are able to control, or protect from, melanoma growth in mice. The data demonstrate the utility of this platform and offer a strategy to… read more here.
Keywords: cd8 cell; dna; ctl responses; launched nanoparticle ... See more keywords