CTLA-4 on thymic epithelial cells complements Aire for T cell central tolerance
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DOI: 10.1073/pnas.2215474119
Abstract: Significance We found that the immunoregulatory receptor CTLA-4 is expressed on mTECs, where it mediates T cell central tolerance. This work deepens our understanding of how T cell tolerance is established and autoimmunity can arise… read more here.
Keywords: thymic epithelial; cell central; ctla thymic; tolerance ... See more keywords