Mice transgenic for human CTLA4-CD28 fusion gene show proliferation and transformation of ATLL-like and AITL-like T cells
Sign Up to like & getrecommendations! Published in 2022 at "Oncoimmunology"
DOI: 10.1080/2162402x.2021.2015170
Abstract: ABSTRACT CTLA4-CD28 gene fusion has been reported to occur in diverse types of T cell lymphoma. The fusion event is expected to convert inhibitory signals to activating signals and promote proliferation and potentially transformation of… read more here.
Keywords: ctla4 cd28; fusion; cd28 fusion; gene ... See more keywords
Genomic landscape of young ATLL patients identifies frequent targetable CD28 fusions.
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood.2019001815
Abstract: Adult T-cell leukemia/lymphoma (ATLL) in Japan presents at a median age of 70 and only 5% of patients are age read more here.
Keywords: landscape young; cd28 fusions; atll; genomic landscape ... See more keywords