Super‐killer CTLs are generated by single gene deletion of Bach2
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202249797
Abstract: Bach2 codes for a transcriptional regulator exerting major influences on T cell‐mediated immune regulation. Effector CTLs derived from in vitro activation of murine CD8+ T cells showed increased proliferative and cytolytic capacity in the absence… read more here.
Keywords: ctls; bach2; super killer; gene deletion ... See more keywords
OCT4&SOX2‐specific cytotoxic T lymphocytes plus programmed cell death protein 1 inhibitor presented with synergistic effect on killing lung cancer stem‐like cells in vitro and treating drug‐resistant lung cancer mice in vivo
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27423
Abstract: This study aimed to investigate the synergistic effect of octamer‐binding transcription factor 4 and sex determining region Y‐box 2 (OCT4&SOX2)‐specific cytotoxic T lymphocytes (CTLs) and programmed cell death protein 1 (PD‐1) inhibitor on killing lung… read more here.
Keywords: inhibitor; group; oct4 sox2; ctls ... See more keywords
Neonatal influenza‐specific effector CTLs retain elevated CD31 levels at the site of infection and have decreased IFN‐γ production
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.4a0518-191r
Abstract: The underlying mechanisms that regulate neonatal immune suppression are poorly characterized. CD31 (PECAM1) is highly expressed on neonatal lymphocytes and is a known modulator of TCR signaling. To further characterize the role of CD31 in… read more here.
Keywords: cd31; effector ctls; ifn production; ctls ... See more keywords
Glypican-3-specific cytotoxic T lymphocytes induced by human leucocyte antigen-A*0201-restricted peptide effectively kill hepatocellular carcinoma cells in vitro.
Sign Up to like & getrecommendations! Published in 2017 at "Asian Pacific journal of tropical medicine"
DOI: 10.1016/j.apjtm.2017.10.013
Abstract: OBJECTIVE To investigate potential human leucocyte antigen (HLA)-A2-restricted epitope peptides of glypican-3 (GPC3) and determine the cytotoxicity of peptide-specific cytotoxic T lymphocytes (CTLs) against hepatocellular carcinoma (HCC) cells. METHODS The potential HLA-A*0201-restricted GPC3 peptides were… read more here.
Keywords: peptide; human leucocyte; gpc3 522; hla ... See more keywords
WT1-specific cytotoxic T lymphocytes induced by activated B cells as apc
Sign Up to like & getrecommendations! Published in 2019 at "Cytotherapy"
DOI: 10.1016/j.jcyt.2019.03.352
Abstract: Background & Aim WT1 is highly expressed in many malignancies including leukemia and targeting WT1 as a Tumor Associated Antigen (TAA) in cancer immunotherapy is attractive. In this study, we induced WT1-specific cytotoxic T lymphocytes… read more here.
Keywords: activated cells; specific ctls; antigen; wt1 specific ... See more keywords
Treatment with Banked 3rd Party Donor Derived Virus Specific T Cells: The Advantages of Pre-Defined HLA restriction and Epitope Specificity
Sign Up to like & getrecommendations! Published in 2020 at "Cytotherapy"
DOI: 10.1016/j.jcyt.2020.03.266
Abstract: Background & Aim For patients lacking a matched donor, transplant (HCT) from umbilical cord or T cell depleted (TCD) grafts, is potentially curative. However, these transplants are associated with high morbidity and mortality from reactivation… read more here.
Keywords: restriction; cmv; specific cells; 3rd party ... See more keywords
Postoperative Adjuvant Therapy for Resectable Pancreatic Cancer With Gemcitabine and Adoptive Immunotherapy
Sign Up to like & getrecommendations! Published in 2017 at "Pancreas"
DOI: 10.1097/mpa.0000000000000880
Abstract: Objectives We previously described adoptive immunotherapy (AIT) with cytotoxic T lymphocytes (CTLs) stimulated by the mucin 1 (MUC1)–expressing human pancreatic cancer cell line YPK-1 (MUC1-CTLs) and demonstrated that MUC1-CTLs might prevent liver metastasis. In the… read more here.
Keywords: muc1 ctls; adoptive immunotherapy; pancreatic cancer; ctls ... See more keywords
Abstract 4107: Cytotoxic T cells armed with IL-4 receptor-targeting and PD-L1-blocking peptides inhibits lung tumor growth
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4107
Abstract: Tumor homing of adoptively transferred cytotoxic T cells (CTLs) to solid tumors is still inefficient. In addition, CTLs that arrive at tumor tissues meet the immune-suppressive tumor microenvironment. To reduce these limitations in adoptive T-cell… read more here.
Keywords: tumor growth; ctls; cytotoxic cells; lung tumor ... See more keywords
B-T Cell Interactions in GRAFT-Versus-Host Disease
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DOI: 10.1182/blood-2020-141277
Abstract: Cytotoxic T cells (CTLs) and B cells engage distinct interactions in GVHD patients' blood and tissues, detectable in regular flow-cytometry screenings, by size and by double positive CD19-CD8 antibody markers (Deola, BMT 2017). B-CTL couplets… read more here.
Keywords: cell interactions; cd19; cd8; ctls ... See more keywords
Adoptive T-Cell Therapy with 3rd Party CMV-pp65-Specific CTLs for CMV Viremia and Disease Arising after Allogeneic Hematopoietic Stem Cell Transplant
Sign Up to like & getrecommendations! Published in 2017 at "Blood"
DOI: 10.1182/blood.v130.suppl_1.747.747
Abstract: Adoptive immunotherapy with transplant donor-derived virus-specific T-cells is effective in the treatment of CMV viremia and disease complicating allogeneic hematopoietic stem cell transplant (HCT), but is not available if the donor is seronegative or unavailable… read more here.
Keywords: cmv; disease; ctls; cell ... See more keywords
Type I interferon suppresses tumor growth through activating the STAT3-granzyme B pathway in tumor-infiltrating cytotoxic T lymphocytes
Sign Up to like & getrecommendations! Published in 2019 at "Journal for Immunotherapy of Cancer"
DOI: 10.1186/s40425-019-0635-8
Abstract: BackgroundType I interferons (IFN-I) have recently emerged as key regulators of tumor response to chemotherapy and immunotherapy. However, IFN-I function in cytotoxic T lymphocytes (CTLs) in the tumor microenvironment is largely unknown.MethodsTumor tissues and CTLs… read more here.
Keywords: ifnar1; tumor infiltrating; ctls; mice ... See more keywords