Molecular Effects of Cardiac Troponin DCM Mutations on Calcium Sensitivity and Myofilament Activation - an Integrated Multi-Scale Modeling Study
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DOI: 10.1016/j.bpj.2016.11.1744
Abstract: Mutations in cTnC (D75Y, E59D and G159D), a key regulatory protein of myofilament contraction, have been associated with dilated cardiomyopathy (DCM). Despite reports of altered myofilament function in these mutants, the underlying molecular alterations caused… read more here.
Keywords: ctnc; calcium sensitivity; molecular effects; multi scale ... See more keywords
Clinical-pathological and immunohistochemical evaluations of cardiac lesions in cats with chronic kidney disease
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DOI: 10.1590/1678-5150-pvb-6739
Abstract: ABSTRACT: Chronic kidney disease (CKD) is characterized by irreversible morphostructural lesions that can progressively evolve to chronic renal insufficiency and kidney failure. It is known that the heart and kidneys are closely related, and that… read more here.
Keywords: cardiac lesions; kidney disease; ctnc antibody; ctnc ... See more keywords