Clinicopathologic Evaluation of CTNNB1 Mutations in High-Intermediate Risk Endometrial Endometrioid Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Gynecological Pathology"
DOI: 10.1097/pgp.0000000000000865
Abstract: CTNNB1 mutations convey increased risk of recurrence in low-risk endometrial endometrioid carcinoma (EEC). Results from previous high-intermediate risk (HIR) cohorts are mixed. The aims of this study were to correlate CTNNB1 mutational status with clinical… read more here.
Keywords: endometrial endometrioid; recurrence; risk; risk endometrial ... See more keywords
High‐resolution melting and immunohistochemical analysis efficiently detects mutually exclusive genetic alterations of adamantinomatous and papillary craniopharyngiomas
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DOI: 10.1111/neup.12408
Abstract: Craniopharyngioma consists of adamantinomatous and papillary subtypes. Recent genetic analysis has demonstrated that the two subtypes are different, not only in clinicopathological features, but also in molecular oncogenesis. Papillary craniopharyngioma (pCP) is characterized by a… read more here.
Keywords: braf v600e; analysis; genetic alterations; mutually exclusive ... See more keywords
The majority of β-catenin mutations in colorectal cancer is homozygous
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DOI: 10.1186/s12885-020-07537-2
Abstract: Background β-catenin activation plays a crucial role for tumourigenesis in the large intestine but except for Lynch syndrome (LS) associated cancers stabilizing mutations of β-catenin gene (CTNNB1) are rare in colorectal cancer (CRC). Previous animal… read more here.
Keywords: catenin; colorectal cancer; crc; ctnnb1 ... See more keywords
Genetic and Methylation Analysis of CTNNB1 in Benign and Malignant Melanocytic Lesions
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DOI: 10.3390/cancers14174066
Abstract: Simple Summary Recurrent CTNNB1 exon 3 mutations have been recognized in the distinct group of melanocytic tumors showing deep penetrating nevus-like morphology and in 1–2% of advanced melanoma. We performed a detailed genetic analysis of… read more here.
Keywords: methylation; ctnnb1 exon; analysis; ctnnb1 ... See more keywords