Effects of the 5'‐Triphosphate Metabolites of Ribavirin, Sofosbuvir, Vidarabine, and Molnupiravir on CTP Synthase. Implications for Repurposing Antiviral Agents Against SARS‐CoV‐2
Sign Up to like & getrecommendations! Published in 2022 at "Chemmedchem"
DOI: 10.1002/cmdc.202200399
Abstract: Repurposing of antiviral drugs affords a rapid and effective strategy to develop therapies to counter pandemics such as COVID‐19. SARS‐CoV‐2 replication is closely linked to the metabolism of cytosine‐containing nucleotides, especially cytidine‐5′‐triphosphate (CTP), such that… read more here.
Keywords: ctp; effects triphosphate; repurposing antiviral; ctp synthase ... See more keywords
Cost-effectiveness of stress CTP versus CTA in detecting obstructive CAD or in-stent restenosis in stented patients
Sign Up to like & getrecommendations! Published in 2020 at "European Radiology"
DOI: 10.1007/s00330-020-07202-z
Abstract: The aim of this retrospective study was to determine cost-effectiveness of stress myocardial CT perfusion (CTP), coronary CT angiography (CTA), and the combination of both in suspected obstructive coronary artery disease (CAD) or in-stent restenosis… read more here.
Keywords: cta ctp; cad; cost; ctp ... See more keywords
Nuclear localization of a novel calpain-2 mediated junctophilin-2 C-terminal cleavage peptide promotes cardiomyocyte remodeling
Sign Up to like & getrecommendations! Published in 2020 at "Basic Research in Cardiology"
DOI: 10.1007/s00395-020-0807-1
Abstract: Heart failure (HF) is a leading cause of morbidity and mortality worldwide. Patients with HF exhibit a loss of junctophilin-2 (JPH2), a structural protein critical in forming junctional membrane complexes in which excitation–contraction takes place.… read more here.
Keywords: nuclear localization; cleavage; jph2 ctp; jph2 ... See more keywords
Novel one-pot ATP regeneration system based on three-enzyme cascade for industrial CTP production
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology Letters"
DOI: 10.1007/s10529-017-2427-x
Abstract: ObjectivesTo develop a new one-pot polyphosphate kinase (PPK) system with low cost and high efficiency for ATP regeneration in industrial CTP production.ResultsWe developed a new one-pot PPK system by applying a three-enzyme cascade (CMK, NDK… read more here.
Keywords: atp regeneration; ctp; system; one pot ... See more keywords
Comparisons of AGRI/FY-4A Cloud Fraction and Cloud Top Pressure with MODIS/Terra Measurements over East Asia
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Meteorological Research"
DOI: 10.1007/s13351-019-8160-8
Abstract: Fengyun-4A (FY-4A), the second generation of China’s geostationary meteorological satellite, provides high spatiotemporal resolution cloud products over East Asia. In this study, cloud fraction (CFR) and cloud top pressure (CTP) products in August 2017 derived… read more here.
Keywords: time lags; east asia; ctp; terra ... See more keywords
Cardiac-specific delivery by cardiac tissue-targeting peptide-expressing exosomes.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.03.227
Abstract: Naturally occurring RNA carriers such as exosomes might be an untapped source of effective delivery vehicles. However, if exosomes are to be exploited for therapeutic applications, they must target specific tissues or cell types to… read more here.
Keywords: heart; delivery; ctp; ctl exo ... See more keywords
Whole-brain CT perfusion on admission predicts delayed cerebral ischemia following aneurysmal subarachnoid hemorrhage.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of radiology"
DOI: 10.1016/j.ejrad.2019.05.008
Abstract: PURPOSE The aim of this study is to prospectively evaluate whole-brain CT perfusion (CTP) on admission to predict delayed cerebral ischemia (DCI) in patients with aneurysmal subarachnoid hemorrhage (aSAH). METHODS All 252 consecutive patients with… read more here.
Keywords: admission; whole brain; brain perfusion; ctp ... See more keywords
Effect of erucic acid on the rheological and surface properties of coal tar pitch
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Adhesion and Adhesives"
DOI: 10.1016/j.ijadhadh.2017.02.014
Abstract: Abstract Coal tar pitch (CTP) was modified using erucic acid, CH3(CH2)7CH=CH(CH2)11COOH, and the rheological and surface properties of the modified CTP were evaluated. The effect of erucic acid was investigated using a rotational viscometer as… read more here.
Keywords: surface properties; coal tar; rheological surface; ctp ... See more keywords
Diagnostic accuracy of semi-automatic quantitative metrics as an alternative to expert reading of CT myocardial perfusion in the CORE320 study.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of cardiovascular computed tomography"
DOI: 10.1016/j.jcct.2018.03.010
Abstract: AIMS To determine the diagnostic accuracy of semi-automatic quantitative metrics compared to expert reading for interpretation of computed tomography perfusion (CTP) imaging. METHODS The CORE320 multicenter diagnostic accuracy clinical study enrolled patients between 45 and… read more here.
Keywords: semi automatic; cta ctp; automatic quantitative; quantitative metrics ... See more keywords
CTP regulates membrane-binding activity of the nucleoid occlusion protein Noc
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Cell"
DOI: 10.1016/j.molcel.2021.06.025
Abstract: Summary ATP- and GTP-dependent molecular switches are extensively used to control functions of proteins in a wide range of biological processes. However, CTP switches are rarely reported. Here, we report that a nucleoid occlusion protein… read more here.
Keywords: membrane binding; ctp; nucleoid occlusion; binding activity ... See more keywords
Critical roles of CTP synthase N-terminal in cytoophidium assembly
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2017.03.042
Abstract: Abstract Several metabolic enzymes assemble into distinct intracellular structures in prokaryotes and eukaryotes suggesting an important functional role in cell physiology. The CTP‐generating enzyme CTP synthase forms long filamentous structures termed cytoophidia in bacteria, yeast,… read more here.
Keywords: ctp synthase; ctp; role; cytoophidium assembly ... See more keywords