Effects of the 5'‐Triphosphate Metabolites of Ribavirin, Sofosbuvir, Vidarabine, and Molnupiravir on CTP Synthase. Implications for Repurposing Antiviral Agents Against SARS‐CoV‐2
Sign Up to like & getrecommendations! Published in 2022 at "Chemmedchem"
DOI: 10.1002/cmdc.202200399
Abstract: Repurposing of antiviral drugs affords a rapid and effective strategy to develop therapies to counter pandemics such as COVID‐19. SARS‐CoV‐2 replication is closely linked to the metabolism of cytosine‐containing nucleotides, especially cytidine‐5′‐triphosphate (CTP), such that… read more here.
Keywords: ctp; effects triphosphate; repurposing antiviral; ctp synthase ... See more keywords
CTP synthase knockdown during early development distorts the nascent vertebral column and causes fluid retention in multiple tissues in zebrafish.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.09.074
Abstract: CTP Synthase (CTPS) is a metabolic enzyme that is recognized as a catalyst for nucleotide, phospholipid and sialoglycoprotein production. Though the structural characteristics and regulatory mechanisms of CTPS are well-understood, little is known regarding the… read more here.
Keywords: column; ctp synthase; synthase knockdown; ctps1a ctps1b ... See more keywords
Critical roles of CTP synthase N-terminal in cytoophidium assembly
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DOI: 10.1016/j.yexcr.2017.03.042
Abstract: Abstract Several metabolic enzymes assemble into distinct intracellular structures in prokaryotes and eukaryotes suggesting an important functional role in cell physiology. The CTP‐generating enzyme CTP synthase forms long filamentous structures termed cytoophidia in bacteria, yeast,… read more here.
Keywords: ctp synthase; ctp; role; cytoophidium assembly ... See more keywords
Ectopic miR-975 induces CTP synthase directed cell proliferation and differentiation in Drosophila melanogaster
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DOI: 10.1038/s41598-019-42369-6
Abstract: CTP synthase (CTPSyn) is an essential metabolic enzyme, synthesizing precursors required for nucleotides and phospholipids production. Previous studies have also shown that CTPSyn is elevated in various cancers. In many organisms, CTPSyn compartmentalizes into filaments… read more here.
Keywords: melanogaster; ctp synthase; drosophila melanogaster; ectopic mir ... See more keywords