Association of lenvatinib plasma concentration with clinical efficacy and adverse events in patients with hepatocellular carcinoma
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DOI: 10.1007/s00280-020-04178-x
Abstract: This study aimed to examine the association between the trough plasma concentration of lenvatinib with the objective response rate (ORR) and adverse events in patients with hepatocellular carcinoma (HCC). Twenty-one patients with HCC who received… read more here.
Keywords: ctrough median; response; group; adverse events ... See more keywords
No difference in effectiveness of treatment simplification to boosted or unboosted atazanavir plus lamivudine in virologically suppressed in HIV-1-infected patients
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DOI: 10.1371/journal.pone.0203452
Abstract: Background Simplification strategies of antiretroviral treatment represent effective tools for the reduction of drug-induced toxicity, resistance mutations in case of virological failure and costs. Objectives To assess the effectiveness of simplification to atazanavir/ritonavir (ATVrtv) or… read more here.
Keywords: treatment; plus lamivudine; hiv; unboosted atazanavir ... See more keywords
Impact of Initial Vancomycin Trough Concentration on Clinical and Microbiological Outcomes of Methicillin-Resistant Staphylococcus aureus Bacteremia in Children
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DOI: 10.3346/jkms.2017.32.1.22
Abstract: It is important to use vancomycin in a proper manner to ensure optimal drug exposure. Despite extensive use of vancomycin in children, studies on its optimal trough concentration (Ctrough) in the pediatric population remained rare.… read more here.
Keywords: vancomycin; resistant staphylococcus; trough concentration; bacteremia ... See more keywords