Epistatic Effects Between Amino Acid Insertions and Substitutions Mediate Toxin resistance of Vertebrate Na+,K+-ATPases
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msac258
Abstract: The recurrent evolution of resistance to cardiotonic steroids (CTS) across diverse animals most frequently involves convergent amino-acid substitutions to the H1-H2 extracellular loop of Na+,K+-ATPase (NKA). Previous work established that hystricognath rodents (e.g. chinchilla) and… read more here.
Keywords: effects amino; acid insertions; resistance; amino acid ... See more keywords
Constraints on the evolution of toxin-resistant Na,K-ATPases have limited dependence on sequence divergence
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Genetics"
DOI: 10.1101/2021.11.29.470343
Abstract: A growing body of theoretical and experimental evidence suggests that intramolecular epistasis is a major determinant of rates and patterns of protein evolution and imposes a substantial constraint on the evolution of novel protein functions.… read more here.
Keywords: dependence; divergence; cts resistance; sequence divergence ... See more keywords