Abstract 6273: CTS3157, a novel MTA-cooperative PRMT5 inhibitor for targeting MTAP-deleted human tumors
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DOI: 10.1158/1538-7445.am2023-6273
Abstract: MTAP deletion is common in about 15% of all human cancers and coincides with the deletion of tumor suppressor locus containing CDKN2A/B. Methylthioadenosine (MTA), the substrate of MTAP, accumulates as a result of MTAP deletion.… read more here.
Keywords: cell; mtap; mta; cts3157 ... See more keywords