Apigenin Alleviated High-Fat-Diet-Induced Hepatic Pyroptosis by Mitophagy-ROS-CTSB-NLRP3 Pathway in Mice and AML12 Cells.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c07581
Abstract: Apigenin is considered the most-known natural flavonoid and is abundant in a wide variety of fruits and vegetables. A high fat diet (HFD) can induce liver injury and hepatocyte death in multiple ways. Pyroptosis is… read more here.
Keywords: ctsb; pyroptosis; aml12 cells; high fat ... See more keywords
Beyond basic research: the contribution of cathepsin B to cancer development, diagnosis and therapy
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2022.2161888
Abstract: ABSTRACT Introduction In view of other candidate proteins from the cathepsin family of proteases holding great potential in being targeted during cancer therapy, the importance of Cathepsin B (CtsB) stands out as being truly exceptional.… read more here.
Keywords: basic research; ctsb; cathepsin; therapy ... See more keywords
Correlation Analysis of CTSB Promoter Polymorphism and Function in Patients with Dilated Cardiomyopathy.
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DOI: 10.1089/dna.2022.0525
Abstract: Dilated cardiomyopathy (DCM) is caused by a combination of genetic susceptibility and environmental factors. Cathepsin B affects the pathogenesis of DCM; however, its molecular mechanism is still unclear. In this study, we examined the association… read more here.
Keywords: ctsb promoter; ctsb; ctsb variants; analysis ... See more keywords
Molecular Cloning, Primary Sequence Characterization and Phylogentic Analysis of Cathepsin B cysteine from Sheep (Ovis aries) Ovarian
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DOI: 10.18805/ijar.b-1290
Abstract: Background: CathepsinB (CTSB) is a lysosomal cysteine protease which has been implicated in a variety of physiological and pathological processes. However, the sequence and structure characteristics of sheep CTSB gene are still unclear, which severely restricts the further… read more here.
Keywords: ctsb; amino; cysteine; analysis ... See more keywords
Characterization of Cathepsin B in Mediating Silica Nanoparticle-Induced Macrophage Pyroptosis via an NLRP3-Dependent Manner
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s371536
Abstract: Introduction Silica nanoparticles (SiNPs) are one of the most widely used inorganic nanomaterials, and exposure to SiNP has been demonstrated to induce pulmonary inflammation, primarily promoted by the NLRP3-mediated macrophage pyroptosis. However, mechanisms underlying the… read more here.
Keywords: macrophage pyroptosis; ctsb; expression nlrp3; pyroptosis ... See more keywords
Zinc enhances autophagic flux and lysosomal function through transcription factor EB activation and V-ATPase assembly
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.895750
Abstract: The stimulation of autophagy or lysosomes has been considered therapeutic for neurodegenerative disorders because the accumulation of misfolded proteins is commonly observed in the brains of individuals with these diseases. Although zinc is known to… read more here.
Keywords: tau; ctsb; zinc; autophagic flux ... See more keywords
Cathepsin B aggravated doxorubicin-induced myocardial injury via NF-κB signalling
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DOI: 10.3892/mmr.2020.11583
Abstract: Myocyte apoptosis and oxidative stress key critical roles in the process of doxorubicin (DOX)-induced cardiotoxicity. However, how apoptosis and oxidative stress arise in DOX-induced heart injury remains largely unknown. Cathepsin B (CTSB) is a typical… read more here.
Keywords: dox induced; ctsb; dox; injury ... See more keywords
Cathepsin B plays a role in spermatogenesis and sperm maturation through regulating autophagy and apoptosis in mice
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DOI: 10.7717/peerj.14472
Abstract: Spermatogenesis and sperm maturation are complex and highly ordered biological processes. Any failure or disorder in these processes can cause defects in sperm morphology, motility, and fertilization ability. Cathepsin B (CTSB) is involved in the… read more here.
Keywords: spermatogenesis sperm; sperm maturation; ctsb; mice ... See more keywords