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   Articles with "ctsd" as a keyword



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Prenatal-onset of congenital neuronal ceroid lipofuscinosis with a novel CTSD mutation.

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recommendations! Published in 2021 at "Birth defects research"

DOI: 10.1002/bdr2.1950

Abstract: BACKGROUND Neuronal ceroid lipofuscinoses (NCLs) form a clinically and genetically heterogeneous group of inherited neurodegenerative disorders that share common neuropathological features. Although they are the first cause of neurodegenerative disorders in children, their congenital forms… read more here.

Keywords: neuronal ceroid; congenital neuronal; onset congenital; ctsd ... See more keywords

Inhibition of Cathepsin D (CTSD) enhances radiosensitivity of glioblastoma cells by attenuating autophagy

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recommendations! Published in 2020 at "Molecular Carcinogenesis"

DOI: 10.1002/mc.23194

Abstract: Postoperative radiotherapy combined with chemotherapy is a commonly used treatment for glioblastoma (GBM) but radiotherapy often fails to achieve the expected results mainly due to tumor radioresistance. In this study, we established a radioresistant subline… read more here.

Keywords: cathepsin ctsd; glioblastoma; ctsd; radiosensitivity glioblastoma ... See more keywords

Regulation of cathepsin D activity by the FTLD protein progranulin

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recommendations! Published in 2017 at "Acta Neuropathologica"

DOI: 10.1007/s00401-017-1719-5

Abstract: and suggest that PGRN and CTSD might function together to regulate lysosomal activities. In support of this hypothesis, granulin motifs are found in cathepsin-like cysteine proteases in plants [11, 16]. These lines of evidence led… read more here.

Keywords: pgrn ctsd; interaction pgrn; ctsd; granulin ... See more keywords

Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy models

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recommendations! Published in 2022 at "Autophagy"

DOI: 10.1080/15548627.2022.2045534

Abstract: ABSTRACT Parkinson disease (PD) is a neurodegenerative disorder characterized by the abnormal intracellular accumulation of SNCA/α-synuclein. While the exact mechanisms underlying SNCA pathology are not fully understood, increasing evidence suggests the involvement of autophagy as… read more here.

Keywords: microscopy; ctsd cathepsin; ctsd; snca ... See more keywords

Circulating Cathepsin D Exacerbates Injury-Induced Brain Damage by Promoting Neutrophil Infiltration Into the Brain.

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recommendations! Published in 2025 at "Journal of the American Heart Association"

DOI: 10.1161/jaha.125.043416

Abstract: Background Communication between the vascular endothelium and peripheral leukocytes is an important process controlling inflammatory responses in the brain. Increased plasma levels of CTSD (cathepsin D) have been associated with vascular events, but whether circulating… read more here.

Keywords: brain; ctsd; injury induced; brain damage ... See more keywords

Zinc enhances autophagic flux and lysosomal function through transcription factor EB activation and V-ATPase assembly

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recommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"

DOI: 10.3389/fncel.2022.895750

Abstract: The stimulation of autophagy or lysosomes has been considered therapeutic for neurodegenerative disorders because the accumulation of misfolded proteins is commonly observed in the brains of individuals with these diseases. Although zinc is known to… read more here.

Keywords: tau; ctsb; zinc; autophagic flux ... See more keywords