Expressions and significances of CTSL, the target of COVID‐19 on GBM
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-021-03843-9
Abstract: Cathepsin L (CTSL) is a kind of the SARS-entry-associated CoV-2's proteases, which plays a key role in the virus's entry into the cell and subsequent infection. We investigated the association between the expression level of… read more here.
Keywords: expression level; gbm; target; level ctsl ... See more keywords
Cathepsin L promotes angiogenesis by regulating the CDP/Cux/VEGF-D pathway in human gastric cancer
Sign Up to like & getrecommendations! Published in 2020 at "Gastric Cancer"
DOI: 10.1007/s10120-020-01080-6
Abstract: Increasing evidence indicates that angiogenesis plays an important role in tumor progression. The function of cathepsin L (CTSL), an endosomal proteolytic enzyme, in promoting tumor metastasis is well recognized. The mechanisms by which CTSL has… read more here.
Keywords: gastric cancer; cdp cux; angiogenesis; ctsl ... See more keywords
Cathepsin L promotes ionizing radiation-induced U251 glioma cell migration and invasion through regulating the GSK-3β/CUX1 pathway.
Sign Up to like & getrecommendations! Published in 2018 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2018.01.012
Abstract: Cathepsin L (CTSL) is a lysosomal cysteine protease overexpressed and secreted by tumor cells. Our previous study found that CTSL was involved in ionizing radiation (IR)-induced epithelial-mesenchymal transition (EMT) and the increase of glioma invasion… read more here.
Keywords: cux1; glioma; invasion; migration invasion ... See more keywords
A miRNA-200c/cathepsin L feedback loop determines paclitaxel resistance in human lung cancer A549 cells in vitro through regulating epithelial–mesenchymal transition
Sign Up to like & getrecommendations! Published in 2017 at "Acta Pharmacologica Sinica"
DOI: 10.1038/aps.2017.164
Abstract: Cathepsin L (CTSL), a cysteine protease, is closely related to tumor occurrence, development, and metastasis, and possibly regulates cancer cell resistance to chemotherapy. miRNAs, especially the miR-200 family, have been implicated in drug-resistant tumors. In… read more here.
Keywords: a549 cells; resistance; cancer; mirna 200c ... See more keywords
Cathepsin L induced PC-12 cell apoptosis via activation of B-Myb and regulation of cell cycle proteins
Sign Up to like & getrecommendations! Published in 2019 at "Acta Pharmacologica Sinica"
DOI: 10.1038/s41401-019-0286-9
Abstract: Cathepsin L (CTSL), a cysteine protease, is responsible for the degradation of a variety of proteins. It is known to participate in neuronal apoptosis associated with abnormal cell cycle. However, the mechanisms underlying CTSL-induced cell… read more here.
Keywords: apoptosis; cell cycle; myb; cell ... See more keywords
Cathepsin L promotes secretory IgA response by participating in antigen presentation pathways during Mycoplasma Hyopneumoniae infection
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0215408
Abstract: Cathepsin L (CTSL) has been proved to help contain leishmaniasis and mycoplasma infection in mice by supporting cellular immune responses, but the regulatory functions of CTSL on mucosal immune responses haven’t been tested and remain… read more here.
Keywords: mycoplasma hyopneumoniae; rctsl; infection; cathepsin ... See more keywords
Cathepsin L promotes chemresistance to neuroblastoma by modulating serglycin
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.920022
Abstract: Cathepsin L (CTSL), a lysosomal acid cysteine protease, is found to play a critical role in chemosencitivity and tumor progression. However, the potential roles and molecular mechanisms of CTSL in chemoresistance in neuroblastoma (NB) are… read more here.
Keywords: cisplatin doxorubicin; cathepsin; ctsl; expression ... See more keywords
Conditional Gene Targeting Reveals Cell Type-Specific Roles of the Lysosomal Protease Cathepsin L in Mammary Tumor Progression
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers12082004
Abstract: Background: Cathepsin L (Ctsl) is a cysteine protease mainly located within the endosomal/lysosomal cell compartment. High expression of Ctsl indicates poor prognosis in human breast cancer. However, the cell type-specific Ctsl functions responsible for this… read more here.
Keywords: type specific; cancer; cell; cell type ... See more keywords
Quinacrine-Induced Autophagy in Ovarian Cancer Triggers Cathepsin-L Mediated Lysosomal/Mitochondrial Membrane Permeabilization and Cell Death
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13092004
Abstract: Simple Summary Ovarian cancer (OC) is the most common cause of cancer-related deaths among women worldwide, and its incidence has been increasing and has continued to prove resistant to a variety of therapeutics. This observation… read more here.
Keywords: cancer; ovarian cancer; cell death; ctsl ... See more keywords
COVID-19 receptor and malignant cancers: Association of CTSL expression with susceptibility to SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.70172
Abstract: CTSL is expressed by cancerous tissues and encodes a lysosomal cysteine proteinase that regulates cancer progression and SARS-CoV-2 entry. Therefore, it is critical to predict the susceptibility of cancer patients for SARS-CoV-2 and evaluate the… read more here.
Keywords: ctsl; ctsl expression; expression ctsl; cancer ... See more keywords