Cyclophosphamide induces ovarian granulosa cell ferroptosis via a mechanism associated with HO-1 and ROS-mediated mitochondrial dysfunction
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DOI: 10.1186/s13048-024-01434-z
Abstract: Abnormal granulosa cell (GC) death contributes to cyclophosphamide (CTX) induced primary ovarian insufficiency (POI). To investigate the contribution of GCs to POI, gene profiles of GCs exposed to CTX were assessed using RNA-Seq and bioinformatics… read more here.
Keywords: ctx; ferroptosis; ferroptosis via; ctx induced ... See more keywords
BFGF mitigates CTX-induced ovarian cytotoxicity via SERPINE1/HIF-1 and Nrf-2/HO-1 signaling pathways
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DOI: 10.1186/s13048-025-01736-w
Abstract: Chemotherapy-induced ovarian damage is a significant concern for female cancer patients, often resulting in infertility, hormonal imbalance, and premature ovarian failure. Cyclophosphamide (CTX), a widely used chemotherapeutic agent, is highly effective against tumors but causes… read more here.
Keywords: induced ovarian; serpine1 hif; ovarian cytotoxicity; ctx induced ... See more keywords
Oligosaccharides from the seeds of Dolichos lablab L. promote gut microbial metabolite L-arginine production to alleviate cyclophosphamide-induced immunosuppression
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DOI: 10.3389/fimmu.2025.1587426
Abstract: Introduction Dolichos lablab L. is a nutritionally and medicinally significant legume, yet research on its bioactive oligosaccharides remains limited. This study investigates the potential of Dolichos lablab L. oligosaccharides to ameliorate cyclophosphamide (CTX)-induced immunosuppression and… read more here.
Keywords: arginine; dolichos lablab; induced immunosuppression; srsv ... See more keywords
Jian-Pi-Bu-Xue-Formula Alleviates Cyclophosphamide-Induced Myelosuppression via Up-Regulating NRF2/HO1/NQO1 Signaling
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DOI: 10.3389/fphar.2020.01302
Abstract: Jian-pi-bu-xue-formula (JPBXF), a TCM formula composed of twelve Chinese medicinal herbs, has been used in clinic to ease patients’ state of weakness and fatigue especially after receiving anti-tumor chemotherapy in China. The lack of the… read more here.
Keywords: induced myelosuppression; ho1 nqo1; ctx induced; jpbxf ... See more keywords
Immunomodulatory Mechanisms of Tea Leaf Polysaccharide in Mice with Cyclophosphamide-Induced Immunosuppression Based on Gut Flora and Metabolomics
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DOI: 10.3390/foods13182994
Abstract: Tea polysaccharides (TPSs) are receiving increasing attention because of their diverse pharmacological and biological activities. Here, we explored the immunoregulatory mechanisms of TPSs from fresh tea leaves in a mouse model of cyclophosphamide (CTX)-induced immunosuppression… read more here.
Keywords: ctx induced; induced immunosuppression; gut microbiota;
Preparation of Auricularia auricula-Derived Immune Modulators and Alleviation of Cyclophosphamide-Induced Immune Suppression and Intestinal Microbiota Dysbiosis in Mice
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DOI: 10.3390/life15081236
Abstract: With the acceleration of the pace of life, increased stress levels, and changes in lifestyle factors such as diet and exercise, the incidence of diseases such as cancer and immunodeficiency has been on the rise,… read more here.
Keywords: mice; induced immune; intestinal microbiota; auricularia auricula ... See more keywords