Rational Control of the Activity of a Cu2+-Dependent DNAzyme by Re-engineering Purely Entropic Intrinsically Disordered Domains.
Sign Up to like & getrecommendations! Published in 2020 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.0c09472
Abstract: The function and activity of many proteins is finely controlled by the modulation of the entropic contribution of intrinsically disordered domains that are not directly involved in any recognition event. Inspired by this mechanism, we… read more here.
Keywords: disordered domains; cu2 dependent; dependent dnazyme; activity ... See more keywords
Further Probing of Cu2+-Dependent PNAzymes Acting as Artificial RNA Restriction Enzymes
Sign Up to like & getrecommendations! Published in 2019 at "Molecules"
DOI: 10.3390/molecules24040672
Abstract: Peptide nucleic acid (PNA)-neocuproine conjugates have been shown to efficiently catalyse the cleavage of RNA target sequences in the presence of Cu2+ ions in a site-specific manner. These artificial enzymes are designed to force the… read more here.
Keywords: pnazyme; cleavage; rna; cu2 dependent ... See more keywords