Dual roles of substituted thiourea as reductant and ligand in CuAAC reaction
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2017.08.029
Abstract: Abstract A highly efficient catalytic system, CuSO 4 ·5H 2 O/1-(4-methoxyphenyl)-3-phenylthiourea, for the copper(I)-catalyzed azide–alkyne cycloaddition reaction (CuAAC) was discovered. In the above catalytic system, substituted thiourea acts both as a reductant and a ligand.… read more here.
Keywords: cuaac; substituted thiourea; cuaac reaction; catalytic system ... See more keywords
Extracellular Electron Transfer Enables Cellular Control of Cu(I)-Catalyzed Alkyne–Azide Cycloaddition
Sign Up to like & getrecommendations! Published in 2022 at "ACS Central Science"
DOI: 10.1021/acscentsci.1c01208
Abstract: Extracellular electron transfer (EET) is an anaerobic respiration process that couples carbon oxidation to the reduction of metal species. In the presence of a suitable metal catalyst, EET allows for cellular metabolism to control a… read more here.
Keywords: control; electron transfer; eet; extracellular electron ... See more keywords
Copper(I)-Catalyzed Alkyne–Azide Cycloaddition (CuAAC) “Click” Reaction: A Powerful Tool for Functionalizing Polyhydroxylated Platforms
Sign Up to like & getrecommendations! Published in 2023 at "ACS Omega"
DOI: 10.1021/acsomega.2c06269
Abstract: Click chemistry is currently one of the most used tools for the generation of complex organic molecules. The advantages of using click chemistry in organic synthesis are remarkable; in many cases, the reactions occur under… read more here.
Keywords: click chemistry; reaction; chemistry; polyhydroxylated platforms ... See more keywords
A flow platform for degradation-free CuAAC bioconjugation
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-06551-0
Abstract: The Cu-catalyzed azide-alkyne cycloaddition (CuAAC) reaction is a cornerstone method for the ligation of biomolecules. However, undesired Cu-mediated oxidation and Cu-contamination in bioconjugates limits biomedical utility. Here, we report a generic CuAAC flow platform for… read more here.
Keywords: flow platform; degradation; cuaac reaction; cuaac ... See more keywords
CuAAC ensembled 1,2,3-triazole linked nanogels for targeted drug delivery: a review
Sign Up to like & getrecommendations! Published in 2023 at "RSC Advances"
DOI: 10.1039/d2ra05592a
Abstract: Copper(i) catalyzed alkyne azide cycloaddition (CuAAC), the quintessential example of ‘click chemistry’, provides an adaptable and adequate platform for the synthesis of nanogels for sustained drug release at targeted sites because of their better biocompatibility.… read more here.
Keywords: targeted drug; cuaac ensembled; drug delivery; drug ... See more keywords
Synthesis of Glycosyl Azides and Their Applications Using CuAAC Click Chemistry to Generate Bis- and Tris(triazolyl)glycosyl Derivatives
Sign Up to like & getrecommendations! Published in 2017 at "Synthesis"
DOI: 10.1055/s-0036-1589090
Abstract: 2,3-Unsaturated C -(triazolyl)glycosyl acetates have been synthesized from 3,4,6-tri- O -acetyl- d -glucal using C -glycosylation and click chemistry and were then used in a palladium-catalyzed Tsuji–Trost type allylic azidation reaction to afford the corresponding… read more here.
Keywords: cuaac; glycosyl derivatives; chemistry; triazolyl glycosyl ... See more keywords