Dual roles of substituted thiourea as reductant and ligand in CuAAC reaction
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2017.08.029
Abstract: Abstract A highly efficient catalytic system, CuSO 4 ·5H 2 O/1-(4-methoxyphenyl)-3-phenylthiourea, for the copper(I)-catalyzed azide–alkyne cycloaddition reaction (CuAAC) was discovered. In the above catalytic system, substituted thiourea acts both as a reductant and a ligand.… read more here.
Keywords: cuaac; substituted thiourea; cuaac reaction; catalytic system ... See more keywords
A flow platform for degradation-free CuAAC bioconjugation
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DOI: 10.1038/s41467-018-06551-0
Abstract: The Cu-catalyzed azide-alkyne cycloaddition (CuAAC) reaction is a cornerstone method for the ligation of biomolecules. However, undesired Cu-mediated oxidation and Cu-contamination in bioconjugates limits biomedical utility. Here, we report a generic CuAAC flow platform for… read more here.
Keywords: flow platform; degradation; cuaac reaction; cuaac ... See more keywords
Recent Advances in Copper-Based Solid Heterogeneous Catalysts for Azide–Alkyne Cycloaddition Reactions
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DOI: 10.3390/ijms23042383
Abstract: The copper(I)-catalyzed azide−alkyne cycloaddition (CuAAC) reaction is considered to be the most representative ligation process within the context of the “click chemistry” concept. This CuAAC reaction, which yields compounds containing a 1,2,3-triazole core, has become… read more here.
Keywords: copper; alkyne cycloaddition; azide alkyne; cuaac reaction ... See more keywords
Exfoliated black phosphorous-mediated CuAAC chemistry for organic and macromolecular synthesis under white LED and near-IR irradiation
Sign Up to like & getrecommendations! Published in 2021 at "Beilstein Journal of Organic Chemistry"
DOI: 10.3762/bjoc.17.164
Abstract: The development of long-wavelength photoinduced copper-catalyzed azide–alkyne click (CuAAC) reaction routes is attractive for organic and polymer chemistry. In this study, we present a novel synthetic methodology for the photoinduced CuAAC reaction utilizing exfoliated two-dimensional… read more here.
Keywords: irradiation; chemistry; led near; cuaac reaction ... See more keywords