Abstract 4368828: CUB domain-containing protein 1 Regulates Extracellular Matrix Remodeling and Src Kinase-Mediated Signaling in Human Cardiac Fibroblasts
Sign Up to like & getrecommendations! Published in 2025 at "Circulation"
DOI: 10.1161/circ.152.suppl_3.4368828
Abstract: Background: Cardiac fibrosis is a critical and independent driver of heart failure (HF), characterized by excessive extracellular matrix (ECM) deposition. Decreased CDCP1 (CUB domain-containing protein 1) expression has been associated with myocardial recovery in human… read more here.
Keywords: containing protein; cdcp1; extracellular matrix; domain containing ... See more keywords
Trp1250, Lys1252, and Arg1367 of ADAMTS13 comprise a hot spot for anti-CUB domain antibodies in patients with iTTP
Sign Up to like & getrecommendations! Published in 2025 at "Blood Advances"
DOI: 10.1182/bloodadvances.2025017193
Abstract: Key Points • Anti–CUB domain antibodies target residues Trp1250, Lys1252, and Arg1367 in patients with iTTP.• Binding of anti-CUB antibodies to ADAMTS13 disrupts spacer-CUB domain interactions, thereby forcing ADAMTS13 in an open conformation. read more here.
Keywords: trp1250 lys1252; domain antibodies; anti cub; cub domain ... See more keywords
CUB Domain-Containing Protein 1 (CDCP1) is a rational target for the development of imaging tracers and antibody-drug conjugates for cancer detection and therapy
Sign Up to like & getrecommendations! Published in 2022 at "Theranostics"
DOI: 10.7150/thno.78171
Abstract: Rationale: An antibody-drug conjugate (ADC) is a targeted therapy consisting of a cytotoxic payload that is linked to an antibody which targets a protein enriched on malignant cells. Multiple ADCs are currently used clinically as… read more here.
Keywords: cub domain; expression; cdcp1; antibody drug ... See more keywords