GCN2 kinase-mediated upregulation of ubiquitin C maintains intracellular glutamine level and tRNAGln (CUG) charging under amino acid starvation.
Sign Up to like & getrecommendations! Published in 2023 at "FEBS letters"
DOI: 10.1002/1873-3468.14628
Abstract: Each tRNA is aminoacylated (charged) with a genetic codon-specific amino acid. It remains unclear what factors are associated with tRNA charging and how tRNA charging is maintained. By using the individual tRNA acylation PCR (i-tRAP)… read more here.
Keywords: glutamine level; acid starvation; cug; amino acid ... See more keywords
Fabrication of Cu-CuG nanocomposites with enhanced mechanical strength and reduced electrical resistivity
Sign Up to like & getrecommendations! Published in 2021 at "Journal of materials research and technology"
DOI: 10.1016/j.jmrt.2021.01.045
Abstract: Abstract Graphene was ball-milled with copper powder to acquire copper-graphene (CuG) powder. One and two percent of CuG in weight were added to stacking layers of fully annealed copper sheets and processed using 2, 4… read more here.
Keywords: reduced electrical; resistivity; copper; cug ... See more keywords
Precise small-molecule recognition of a toxic CUG RNA repeat expansion.
Sign Up to like & getrecommendations! Published in 2017 at "Nature chemical biology"
DOI: 10.1038/nchembio.2251
Abstract: Excluding the ribosome and riboswitches, developing small molecules that selectively target RNA is a longstanding problem in chemical biology. A typical cellular RNA is difficult to target because it has little tertiary, but abundant secondary… read more here.
Keywords: cug; recognition; biology; repeat expansion ... See more keywords
Evolutionary instability of CUG-Leu in the genetic code of budding yeasts
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-04374-7
Abstract: The genetic code used in nuclear genes is almost universal, but here we report that it changed three times in parallel during the evolution of budding yeasts. All three changes were reassignments of the codon… read more here.
Keywords: cug; code; budding yeasts; evolutionary instability ... See more keywords
Proteogenomics analysis of CUG codon translation in the human pathogen Candida albicans
Sign Up to like & getrecommendations! Published in 2021 at "BMC Biology"
DOI: 10.1186/s12915-021-01197-9
Abstract: Background Yeasts of the CTG-clade lineage, which includes the human-infecting Candida albicans , Candida parapsilosis and Candida tropicalis species, are characterized by an altered genetic code. Instead of translating CUG codons as leucine, as happens… read more here.
Keywords: cug codons; mistranslation; cug; trna ... See more keywords
In silico discovery of substituted pyrido[2,3-d]pyrimidines and pentamidine-like compounds with biological activity in myotonic dystrophy models
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0178931
Abstract: Myotonic dystrophy type 1 (DM1) is a rare multisystemic disorder associated with an expansion of CUG repeats in mutant DMPK (dystrophia myotonica protein kinase) transcripts; the main effect of these expansions is the induction of… read more here.
Keywords: dm1; biological activity; myotonic dystrophy; cug ... See more keywords
Longitudinal study of the newborn small for gestational age. Growth recovery and conditioning factors.
Sign Up to like & getrecommendations! Published in 2022 at "Nutricion hospitalaria"
DOI: 10.20960/nh.03907
Abstract: BACKGROUND small-for-gestational-age (SGA) newborns present a higher morbidity and mortality rate when compared to infants born appropriate for gestational age (AGA), as well as insufficient growth, with height far from their target and in some… read more here.
Keywords: growth; cug; gestational age; sgas ... See more keywords
Altered Liver Metabolism, Mitochondrial Function, Oxidative Status, and Inflammatory Response in Intrauterine Growth Restriction Piglets with Different Growth Patterns before Weaning
Sign Up to like & getrecommendations! Published in 2022 at "Metabolites"
DOI: 10.3390/metabo12111053
Abstract: Frequent occurrence of intrauterine growth restriction (IUGR) causes huge economic losses in the pig industry. Accelerated catch-up growth (CUG) in the early stage of life could restore multiple adverse outcomes of IUGR offspring; however, there… read more here.
Keywords: metabolism; function; growth; cug ... See more keywords