Precise small-molecule recognition of a toxic CUG RNA repeat expansion.
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DOI: 10.1038/nchembio.2251
Abstract: Excluding the ribosome and riboswitches, developing small molecules that selectively target RNA is a longstanding problem in chemical biology. A typical cellular RNA is difficult to target because it has little tertiary, but abundant secondary… read more here.
Keywords: cug; recognition; biology; repeat expansion ... See more keywords