Synthesis of Chiral β,β-Disubstituted Ketones via CuH-Catalyzed Coupling of Aryl Alkenes and 3-Aryl-2H-azirines.
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DOI: 10.1021/acs.orglett.2c03311
Abstract: A CuH-catalyzed coupling of aryl alkenes with 3-aryl-2H-azirines has been developed to synthesize optically active β,β-disubstituted ketones. We propose that this protocol occurs through a sequence in which a chiral alkylcopper complex regioselectively attacks the… read more here.
Keywords: disubstituted ketones; coupling aryl; cuh catalyzed; aryl alkenes ... See more keywords
CuH-Catalyzed Enantioselective Desymmetrization of Cyclic 1,3-Diketones.
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DOI: 10.1021/acs.orglett.2c03359
Abstract: Herein, we report a CuH-catalyzed asymmetric desymmetrization of prochiral cyclopentane-1,3-diones to access cyclic 3-hydroxy ketones having an all-carbon quaternary center with high diastereoselectivity via hydrosilylation using PMHS as an inexpensive hydride source. This reaction displays… read more here.
Keywords: cuh catalyzed; desymmetrization cyclic; desymmetrization; enantioselective desymmetrization ... See more keywords
Synthesis of Pyrroles Through the CuH-Catalyzed Coupling of Enynes and Nitriles.
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DOI: 10.1021/jacs.0c03859
Abstract: Herein, we describe an efficient method to prepare polysubstituted pyrroles via a copper-hydride (CuH)-catalyzed enyne-nitrile coupling reaction. This protocol accommodates both aromatic and aliphatic substituents and a broad range of functional groups, providing a variety… read more here.
Keywords: cuh catalyzed; enynes nitriles; synthesis pyrroles; catalyzed coupling ... See more keywords