Autism-linked Cullin3 germline haploinsufficiency impacts cytoskeletal dynamics and cortical neurogenesis through RhoA signaling
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DOI: 10.1038/s41380-021-01052-x
Abstract: E3-ubiquitin ligase Cullin3 ( Cul3 ) is a high confidence risk gene for autism spectrum disorder (ASD) and developmental delay (DD). To investigate how Cul3 mutations impact brain development, we generated a haploinsufficient Cul3 mouse… read more here.
Keywords: cul3 mutant; rhoa; autism; neurogenesis ... See more keywords