Integrated analysis of patients with KEAP1/NFE2L2/CUL3 mutations in lung adenocarcinomas.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer medicine"
DOI: 10.1002/cam4.4338
Abstract: OBJECTIVES To explore the clinical features, molecular characteristics, and immune landscape of lung adenocarcinoma patients with KEAP1/NFE2L2/CUL3 mutations. METHODS The multi-omics data from the GDC-TCGA LUAD project of The Cancer Genome Atlas (TCGA) database were downloaded… read more here.
Keywords: cul3 mutations; patients keap1; analysis; keap1 nfe2l2 ... See more keywords
Renal effects of cullin 3 mutations causing familial hyperkalemic hypertension.
Sign Up to like & getrecommendations! Published in 2023 at "Current opinion in nephrology and hypertension"
DOI: 10.1097/mnh.0000000000000891
Abstract: PURPOSE OF REVIEW Mutations in the E3 ubiquitin ligase scaffold cullin 3 (CUL3) cause the disease familial hyperkalemic hypertension (FHHt) by hyperactivating the NaCl cotransporter (NCC). The effects of these mutations are complex and still… read more here.
Keywords: hypertension; familial hyperkalemic; hyperkalemic hypertension; cul3 mutations ... See more keywords