Cullin 4A/protein arginine methyltransferase 5 (CUL4A/PRMT5) promotes cell malignant phenotypes and tumor growth in nasopharyngeal carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2054756
Abstract: ABSTRACT Targeted therapy is an important therapeutic strategy currently, however, the development of targeted therapy for nasopharyngeal carcinoma (NPC) is relatively lagging. Cullin 4A (CUL4A) was reported to be overexpressed in NPC; nevertheless, the specific… read more here.
Keywords: nasopharyngeal carcinoma; tumor growth; cul4a; tumor ... See more keywords
Reduced miR-363-3p expression in non-small cell lung cancer is associated with gemcitabine resistance via targeting of CUL4A.
Sign Up to like & getrecommendations! Published in 2019 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_201901_16879
Abstract: OBJECTIVE Accumulating evidence has suggested that aberrant expression of microRNAs (miRNAs) is associated with non-small cell lung cancer (NSCLC) proliferation, migration, invasion and chemotherapy resistance. Cullin4A (CUL4A) has been previously reported to desensitize NSCLC cells… read more here.
Keywords: cul4a; mir 363; expression; resistance ... See more keywords
Autophagy Plays a Role in the CUL4A-Related Poor Prognosis of Intrahepatic Cholangiocarcinoma
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DOI: 10.3389/pore.2021.602714
Abstract: CUL4A regulate the termination of autophagy in a physical process. However, the relationship between CUL4A and autophagy in cancer is unclear. We retrospectively investigated 99 intrahepatic cholangiocarcinoma (iCCA) cases. Whole sections were used for immunohistochemical… read more here.
Keywords: icca; poor prognosis; cul4a; intrahepatic cholangiocarcinoma ... See more keywords
Cul4a attenuates LPS-induced acute kidney injury via blocking NF-κB signaling pathway in sepsis
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DOI: 10.5937/jomb0-33096
Abstract: Background: Acute kidney injury (AKI) is a common disease that can develop into end-stage kidney disease. Sepsis is one of the main causes of AKI. Currently, there is no satisfactory way to treat septic AKI.… read more here.
Keywords: kidney injury; lps induced; septic aki; cul4a ... See more keywords