Activation of TNF‐α/NF‐κB axis enhances CRL4BDCAF 11 E3 ligase activity and regulates cell cycle progression in human osteosarcoma cells
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12176
Abstract: Cullin 4B, a member of the Cullins, which serve as scaffolds to facilitate the assembly of E3 ligase complexes, is aberrantly expressed in many cancers, including osteosarcoma. Recently, we observed that CUL4B forms the CRL4BDCAF11… read more here.
Keywords: ligase; osteosarcoma; tnf axis; osteosarcoma cells ... See more keywords
Knockdown of circMFN2 inhibits cell progression and glycolysis by miR-198/CUL4B pathway in ovarian cancer.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.23383
Abstract: Circular RNA (circRNA) regulates malignant tumors, including ovarian cancer (OC). The present research study aimed to reveal the biological mechanism of circRNA mitofusin 2 (circMFN2) in OC. Cell biological behaviors were investigated using clonogenicity assay,… read more here.
Keywords: cul4b; ovarian cancer; circmfn2; glycolysis ... See more keywords
CRL4BRBBP7 targets HUWE1 for ubiquitination and proteasomal degradation.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.05.008
Abstract: The E3 ubiquitin ligase HUWE1/Mule/ARF-BP1 plays an important role in diverse biological processes including DNA damage repair and apoptosis. Our previous study has shown that in response to DNA damage HUWE1 was downregulated in CUL4B-mediated… read more here.
Keywords: dna damage; degradation; huwe1; proteasomal degradation ... See more keywords
CUL4B promotes gastric cancer invasion and metastasis-involvement of upregulation of HER2
Sign Up to like & getrecommendations! Published in 2018 at "Oncogene"
DOI: 10.1038/onc.2017.380
Abstract: Cullin 4B (CUL4B) is a scaffold protein overexpressed in several solid malignancies. It is known to silence tumor suppressor through post-transcriptional manner. However, its clinical significance and underlying molecular mechanisms in gastric cancer (GC) remain… read more here.
Keywords: gastric cancer; metastasis; cul4b promotes; her2 ... See more keywords
Inhibition of MicroRNA miR-101-3p on prostate cancer progression by regulating Cullin 4B (CUL4B) and PI3K/AKT/mTOR signaling pathways.
Sign Up to like & getrecommendations! Published in 2021 at "Bioengineered"
DOI: 10.1080/21655979.2021.1949513
Abstract: To probe into the efffects of miR-101-3p via regulating CUL4B within PI3K/AKT/mTOR signaling pathway on progression of prostate cancer (PCA). Western blot and qRT-PCR were adopted to detect CUL4B and miR-101-3p expressions in 75 cases… read more here.
Keywords: mir 101; mtor signaling; pi3k akt; akt mtor ... See more keywords
Cullin4B Induces Autophagy Participating the Tumorigenesis of Diffuse Large B-Cell Lymphoma
Sign Up to like & getrecommendations! Published in 2017 at "Blood"
DOI: 10.1182/blood.v130.suppl_1.2541.2541
Abstract: Background: Cullin 4B(CUL4B) is a member of cullin family, which is a scaffold protein of Cullin-Ring ligase complexes. CUL4B has been reported to be overexpressed in many solid cancers. And evidence supporting the oncogenic role… read more here.
Keywords: tumorigenesis; dlbcl; dlbcl cells; cell ... See more keywords