Cullin 4-DCAF Proteins in Tumorigenesis.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-15-1025-0_15
Abstract: Cullin-RING ligase 4 (CRL4), a member of the cullin-RING ligase family, orchestrates a variety of critical cellular processes and pathophysiological events. Recent results from mouse genetics, clinical analyses, and biochemical studies have revealed the impact… read more here.
Keywords: cullin; etiology; dcaf proteins; proteins tumorigenesis ... See more keywords
Assembly and Regulation of CRL Ubiquitin Ligases.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-15-1025-0_3
Abstract: Cullin-RING ubiquitin ligases (CRLs) determine the substrate specificity of ubiquitination reactions, and substrates are recruited to the cullin core through binding to their cognate substrate receptor modules. Because a family of substrate receptors compete for… read more here.
Keywords: protein; assembly regulation; cullin; crl ... See more keywords
Cullin E3 Ligase Activity Is Required for Myoblast Differentiation.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2017.02.012
Abstract: The role of cullin E3-ubiquitin ligases for muscle homeostasis is best known during muscle atrophy, as the cullin-1 substrate adaptor atrogin-1 is among the most well-characterized muscle atrogins. We investigated whether cullin activity was also… read more here.
Keywords: cullin; muscle; differentiation; activity ... See more keywords
NEDD8-its role in the regulation of Cullin-RING ligases.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in plant biology"
DOI: 10.1016/j.pbi.2018.05.017
Abstract: The ubiquitin-related protein NEDD8 is conjugated and deconjugated to and from proteins in processes related to ubiquitin conjugation and deconjugation. Neddylation is a well-studied posttranslational modification of Cullin-RING E3 ligases (CRLs). Biochemical and structural studies… read more here.
Keywords: cullin ring; ring ligases; cullin; neddylation ... See more keywords
Cullin neddylation inhibitor attenuates hyperglycemia by enhancing hepatic insulin signaling through insulin receptor substrate stabilization
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2111737119
Abstract: Significance Hepatic insulin resistance is a well-recognized cause of hepatic glucose overproduction and fasting hyperglycemia in fatty liver disease and type-2 diabetes. Here, we have discovered that pharmacological inhibition of cullin neddylation by NAE1 inhibitor… read more here.
Keywords: cullin neddylation; cullin; insulin signaling; insulin ... See more keywords
NEDDylated Cullin 3 mediates the adaptive response to topoisomerase 1 inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abq0648
Abstract: DNA topoisomerase 1 (TOP11) inhibitors are mainstays of anticancer therapy. These drugs trap TOP1 on DNA, stabilizing the TOP1-cleavage complex (TOP1-cc). The accumulation of TOP1-ccs perturbs DNA replication fork progression, leading to DNA breaks and… read more here.
Keywords: dna; adaptive response; topoisomerase; top1 ... See more keywords
Ubiquitination of NKCC2 by the cullin-RING E3 ubiquitin ligase family in the thick ascending limb of the loop of Henle
Sign Up to like & getrecommendations! Published in 2023 at "American Journal of Physiology - Renal Physiology"
DOI: 10.1152/ajprenal.00079.2022
Abstract: The Na/K/2Cl cotransporter (NKCC2) in the thick ascending limb of the loop of Henle (TAL) mediates NaCl reabsorption. Cyclic guanosine monophosphate (cGMP), the second messenger of nitric oxide and atrial natriuretic peptide, inhibits NKCC2 activity… read more here.
Keywords: nkcc2 ubiquitination; ubiquitin ligase; physiology; crl complex ... See more keywords
Targeting Protein Neddylation to Inactivate Cullin-RING Ligases by Gossypol: A Lucky Hit or a New Start?
Sign Up to like & getrecommendations! Published in 2021 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s286373
Abstract: Abstract Cullin-RING E3 ligases (CRLs) are the largest family of E3 ubiquitin ligases, responsible for about 20% of the protein degradation by the ubiquitin-proteasome system (UPS). Given their vital roles in multiple cellular processes, and… read more here.
Keywords: cullin ring; cullin neddylation; ring ligases; neddylation ... See more keywords