Targeting Cullin-RING Ubiquitin Ligases and the Applications in PROTACs.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-15-1025-0_19
Abstract: Cullin-RING ligases (CRLs), the largest family of E3 ubiquitin ligases, have become an attractive target for drug discovery, primarily due to their ability to regulate the degradation of numerous functionally and structurally diverse proteins, thereby… read more here.
Keywords: cullin ring; ring ubiquitin; targeting cullin; ubiquitin ligases ... See more keywords
Coordinated Actions Between p97 and Cullin-RING Ubiquitin Ligases for Protein Degradation.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-15-1025-0_5
Abstract: The cullin-RING ubiquitin ligases comprise the largest subfamily of ubiquitin ligases. They control ubiquitylation and degradation of a large number of protein substrates in eukaryotes. p97 is an ATPase domain-containing protein segregase. It plays essential… read more here.
Keywords: cullin ring; ring ubiquitin; ubiquitin ligases; coordinated actions ... See more keywords
Regulation of Stem Cells by Cullin-RING Ligase.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-15-1025-0_6
Abstract: Stem cells can remain quiescent, self-renewal, and differentiate into many types of cells and even cancer stem cells. The coordination of these complex processes maintains the homeostasis of the organism. Ubiquitination is an important posttranslational… read more here.
Keywords: cells cullin; cullin ring; stem cell; stem ... See more keywords
Viral Manipulations of the Cullin-RING Ubiquitin Ligases.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-15-1025-0_7
Abstract: Cullin-RING ubiquitin ligases (CRLs) are efficient and diverse toolsets of the cells to regulate almost every biological process. However, these characteristics have also been usurped by many viruses to optimize for their replication. CRLs are… read more here.
Keywords: cullin ring; viral manipulations; ring ubiquitin; ubiquitin ligases ... See more keywords
Plasticity of the Cullin-RING Ligase Repertoire Shapes Sensitivity to Ligand-Induced Protein Degradation.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular cell"
DOI: 10.1016/j.molcel.2019.07.013
Abstract: Inducing protein degradation via small molecules is a transformative therapeutic paradigm. Although structural requirements of target degradation are emerging, mechanisms determining the cellular response to small-molecule degraders remain poorly understood. To systematically delineate effectors required for… read more here.
Keywords: degradation; cullin ring; sensitivity; plasticity cullin ... See more keywords
NEDD8-its role in the regulation of Cullin-RING ligases.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in plant biology"
DOI: 10.1016/j.pbi.2018.05.017
Abstract: The ubiquitin-related protein NEDD8 is conjugated and deconjugated to and from proteins in processes related to ubiquitin conjugation and deconjugation. Neddylation is a well-studied posttranslational modification of Cullin-RING E3 ligases (CRLs). Biochemical and structural studies… read more here.
Keywords: cullin ring; ring ligases; cullin; neddylation ... See more keywords
Targeting Protein Neddylation to Inactivate Cullin-RING Ligases by Gossypol: A Lucky Hit or a New Start?
Sign Up to like & getrecommendations! Published in 2021 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s286373
Abstract: Abstract Cullin-RING E3 ligases (CRLs) are the largest family of E3 ubiquitin ligases, responsible for about 20% of the protein degradation by the ubiquitin-proteasome system (UPS). Given their vital roles in multiple cellular processes, and… read more here.
Keywords: cullin ring; cullin neddylation; ring ligases; neddylation ... See more keywords
Identification of hypertrophy-modulating Cullin-RING ubiquitin ligases in primary cardiomyocytes
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2023.1134339
Abstract: Cullin-RING ubiquitin ligases (CRL) regulate numerous biological processes in the heart and have been implicated in regulating cardiac hypertrophy. This study aimed to identify novel hypertrophy-modulating CRLs in cardiomyocytes (CM). A functional genomic approach using… read more here.
Keywords: ring ubiquitin; hypertrophy; depletion; fbxo25 ... See more keywords
SENP8 limits aberrant neddylation of NEDD8 pathway components to promote cullin-RING ubiquitin ligase function
Sign Up to like & getrecommendations! Published in 2017 at "eLife"
DOI: 10.7554/elife.24325
Abstract: NEDD8 is a ubiquitin-like modifier most well-studied for its role in activating the largest family of ubiquitin E3 ligases, the cullin-RING ligases (CRLs). While many non-cullin neddylation substrates have been proposed over the years, validation… read more here.
Keywords: neddylation; cullin ring; pathway components; aberrant neddylation ... See more keywords