Interim Effectiveness and Safety Comparison of Bedaquiline-Containing Regimens for Treatment of Diabetic Versus Non-Diabetic MDR/XDR-TB Patients in China: A Multicenter Retrospective Cohort Study
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DOI: 10.1007/s40121-021-00396-9
Abstract: Introduction Diabetes mellitus (DM), a common tuberculosis (TB) comorbidity, is associated with delayed bacillary clearance during anti-TB treatment and unfavorable outcomes. Bedaquiline (BDQ), when used as part of multidrug regimen for multidrug-resistant/extensively drug-resistant tuberculosis (MDR/XDR-TB),… read more here.
Keywords: week; treatment; culture conversion; study ... See more keywords
Factors associated with sputum culture conversion in patients with pulmonary tuberculosis.
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DOI: 10.1016/j.medici.2018.01.005
Abstract: OBJECTIVE The aim of this study was to determine what factors are associated with sputum culture conversion after 1 month of tuberculosis (TB) treatment. MATERIALS AND METHODS A total of 52 patients with new drug… read more here.
Keywords: culture conversion; treatment; conversion; tuberculosis ... See more keywords
1468. Culture Conversion and Mortality in Patients With Mycobacterium abscessus (MAB) Lung Disease: A Systematic Literature Review
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DOI: 10.1093/ofid/ofaa439.1649
Abstract: Prognosis for patients with MAB lung disease is poor. We sought to examine the potential association between culture conversion and outcomes (progression, mortality) in patients with MAB lung disease. English-language MAB lung disease studies with… read more here.
Keywords: culture conversion; lung disease; mortality; culture ... See more keywords
Time to Culture Conversion of Bedaquiline and High-Dose Isoniazid for Drug-Resistant Tuberculosis
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DOI: 10.1093/ofid/ofac440
Abstract: Abstract Patients with multidrug-resistant tuberculosis who received regimens containing high-dose isoniazid (INHHD) had similar time to culture conversion and treatment outcomes as patients who received regimens with bedaquiline. INHHD is an inexpensive and safe medication… read more here.
Keywords: dose isoniazid; time culture; resistant tuberculosis; culture conversion ... See more keywords
Early culture conversion is a poor marker of treatment outcome among people with HIV and drug‐resistant TB
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DOI: 10.1111/hiv.13392
Abstract: Our objective was to determine associations between early (≤2 months) culture conversion (ECC) among people with HIV and drug‐resistant tuberculosis (DRTB) in Uganda. read more here.
Keywords: people hiv; among people; hiv drug; culture conversion ... See more keywords
Fluoroquinolones in Drug-Resistant Tuberculosis: Culture Conversion and Pharmacokinetic/Pharmacodynamic Target Attainment To Guide Dose Selection
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DOI: 10.1128/aac.00279-19
Abstract: Fluoroquinolones are group A drugs in tuberculosis guidelines. We aim to compare the culture conversion between new-generation (levofloxacin and moxifloxacin) and old-generation (ciprofloxacin and ofloxacin) fluoroquinolones, develop pharmacokinetic models, and calculate target attainment for levofloxacin… read more here.
Keywords: target attainment; culture conversion; generation; culture ... See more keywords
Linezolid Experience Among MDR-TB Patients in Mumbai
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DOI: 10.1183/1393003.congress-2017.pa3486
Abstract: Background: India has 25% of the world’s tuberculosis. Mumbai is home to 12% of India’s cases that are resistant to rifampin and isoniazid (MDR-TB), but they are often resistant to standard treatment. Linezolid (LZD) resistance… read more here.
Keywords: experience among; culture conversion; lzd; mdr patients ... See more keywords
Substitution of ethambutol with linezolid during the intensive phase of treatment of pulmonary tuberculosis: study protocol for a prospective, multicenter, randomized, open-label, phase II trial
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DOI: 10.1186/s13063-017-1811-0
Abstract: BackgroundLinezolid, an oxazolidinone, substantially improves treatment outcomes of multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis. We started a trial to test whether the use of linezolid instead of ethambutol could increase the rate of sputum culture… read more here.
Keywords: phase; treatment; culture conversion; tuberculosis ... See more keywords
Time for culture conversion and its associated factors in multidrug-resistant tuberculosis patients at a tertiary level hospital in Peshawar, Pakistan
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DOI: 10.12669/pjms.38.4.5058
Abstract: Objectives: This study aimed to assess the time to sputum culture conversion (SCC) and its determinants among multidrug-resistant tuberculosis (MDR-TB) patients. Methods: This cross-sectional study was conducted from January 2019 to January 2020. A total… read more here.
Keywords: culture; time; resistant tuberculosis; multidrug resistant ... See more keywords
Comparison of the validity of smear and culture conversion as a prognostic marker of treatment outcome in patients with multidrug-resistant tuberculosis
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DOI: 10.1371/journal.pone.0197880
Abstract: Background The World Health Organization (WHO) has conditionally recommended the use of sputum smear microscopy and culture examination for the monitoring of multidrug-resistant tuberculosis (MDR-TB) treatment. We aimed to assess and compare the validity of… read more here.
Keywords: smear conversion; treatment; smear culture; conversion ... See more keywords
Evaluation of six months sputum culture conversion as a surrogate endpoint in a multidrug resistant-tuberculosis trial
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DOI: 10.1371/journal.pone.0200539
Abstract: The emergence of multidrug resistant-tuberculosis (MDR-TB), defined as Mycobacterium tuberculosis strains with in vitro resistance to at least isoniazid and rifampicin, has necessitated evaluation and validation of appropriate surrogate endpoints for treatment response in drug… read more here.
Keywords: culture conversion; surrogate; evaluation; culture ... See more keywords