Hepatitis C virus cell culture models: an encomium on basic research paving the road to therapy development
Sign Up to like & getrecommendations! Published in 2018 at "Medical Microbiology and Immunology"
DOI: 10.1007/s00430-018-0566-x
Abstract: Chronic hepatitis C virus (HCV) infections affect 71 million people worldwide, often resulting in severe liver damage. Since 2014 highly efficient therapies based on directly acting antivirals (DAAs) are available, offering cure rates of almost 100%,… read more here.
Keywords: cell culture; therapy development; hepatitis virus; culture models ... See more keywords
Progression of conventional hepatic cell culture models to bioengineered HepG2 cells for evaluation of herbal bioactivities
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology Letters"
DOI: 10.1007/s10529-018-2547-y
Abstract: Cancer cell lines of human tissue origin have been extensively used to investigate antiproliferative activity and toxicity of herbal extracts, isolated compounds, and anticancer drugs. These cell lines are genetically and/or epigenetically well characterized to… read more here.
Keywords: hepatoma; cell culture; hepg2 cells; culture models ... See more keywords
Three-dimensional culture models to study glioblastoma - current trends and future perspectives.
Sign Up to like & getrecommendations! Published in 2021 at "Current opinion in pharmacology"
DOI: 10.1016/j.coph.2021.08.019
Abstract: Glioblastoma (GBM) is the most prevalent form of primary malignant brain tumor in adults and remains almost invariably lethal owing to its aggressive and invasive nature. There have only been marginal improvements in its bleak… read more here.
Keywords: three dimensional; dimensional culture; biology; culture models ... See more keywords
Three-dimensional in vitro tissue culture models of brain organoids
Sign Up to like & getrecommendations! Published in 2021 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2021.113619
Abstract: Brain organoids are three-dimensional self-assembled structures that are derived from human induced pluripotent stem cells (hiPSCs). They can recapitulate the spatiotemporal organization and function of the brain, presenting a robust system for in vitro modeling… read more here.
Keywords: three dimensional; organoids three; brain organoids; culture models ... See more keywords
Different co-culture models reveal the pivotal role of TBBPA-promoted M2 macrophage polarization in the deterioration of endometrial cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of hazardous materials"
DOI: 10.1016/j.jhazmat.2021.125337
Abstract: Tetrabromobisphenol A (TBBPA), an emerging organic pollutant widely detected in human samples, has a positive correlation with the development of endometrial cancer (EC), but its underlying mechanisms have not yet been fully elucidated. Tumor-associated macrophages… read more here.
Keywords: tbbpa; culture models; macrophage polarization;
A review of co-culture models to study the oral microenvironment and disease
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Oral Microbiology"
DOI: 10.1080/20002297.2020.1773122
Abstract: ABSTRACT Co-cultures allow for the study of cell–cell interactions between different eukaryotic species or with bacteria. Such an approach has enabled researchers to more closely mimic complex tissue structures. This review is focused on co-culture… read more here.
Keywords: review culture; disease; culture models; culture ... See more keywords
How relevant are in vitro culture models for study of tick-pathogen interactions?
Sign Up to like & getrecommendations! Published in 2021 at "Pathogens and global health"
DOI: 10.1080/20477724.2021.1944539
Abstract: Although tick-borne infectious diseases threaten human and animal health worldwide, with constantly increasing incidence, little knowledge is available regarding vector-pathogen interactions and pathogen transmission. In vivo laboratory study of these subjects using live, intact ticks… read more here.
Keywords: pathogen; study tick; tick borne; culture models ... See more keywords
Cell culture models of oral mucosal barriers: A review with a focus on applications, culture conditions and barrier properties
Sign Up to like & getrecommendations! Published in 2018 at "Tissue Barriers"
DOI: 10.1080/21688370.2018.1479568
Abstract: ABSTRACT Understanding the function of oral mucosal epithelial barriers is essential for a plethora of research fields such as tumor biology, inflammation and infection diseases, microbiomics, pharmacology, drug delivery, dental and biomarker research. The barrier… read more here.
Keywords: barrier; oral mucosal; cell culture; barrier properties ... See more keywords
3D Culture Models of Malignant Mesothelioma Reveal a Powerful Interplay Between Photodynamic Therapy and Kinase Suppression Offering Hope to Reduce Tumor Recurrence
Sign Up to like & getrecommendations! Published in 2019 at "Photochemistry and Photobiology"
DOI: 10.1111/php.13059
Abstract: In this issue, Cramer et al. introduce 3D culture models of metastatic mesothelioma to investigate basic cancer biology and new combination therapies for combating this complex and lethal disease. The results suggest that erlotinib‐enhanced photodynamic… read more here.
Keywords: culture models; models malignant; photodynamic therapy; tumor ... See more keywords
mSphere of Influence: 3-D Culture Models Influence Studies on Epstein-Barr Virus Molecular Pathogenesis in the Epithelium
Sign Up to like & getrecommendations! Published in 2020 at "mSphere"
DOI: 10.1128/msphere.00954-20
Abstract: Kathy Shair works in the field of Epstein-Barr virus (EBV)-associated cancers, with emphasis on nasopharyngeal carcinoma (NPC). In this mSphere of Influence article, she reflects on how the paper “Efficient replication of Epstein-Barr virus in… read more here.
Keywords: barr virus; molecular pathogenesis; culture models; msphere influence ... See more keywords
Emerging organoid-immune co-culture models for cancer research: from oncoimmunology to personalized immunotherapies
Sign Up to like & getrecommendations! Published in 2023 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-006290
Abstract: In the past decade, treatments targeting the immune system have revolutionized the cancer treatment field. Therapies such as immune checkpoint inhibitors have been approved as first-line treatment in a variety of solid tumors such as… read more here.
Keywords: culture models; organoid immune; immune culture; immune interactions ... See more keywords