Interaction of cell culture process parameters for modulating mAb afucosylation
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DOI: 10.1002/bit.26908
Abstract: The extent of afucosylation, which refers to the absence of core fucose on Fc glycans, can correlate positively with the antibody‐dependent cellular cytotoxicity (ADCC) activity of a monoclonal antibody (mAb). Therefore, it is important to… read more here.
Keywords: cell culture; culture; culture process; afucosylation ... See more keywords
Kinetic modeling as a tool to understand the influence of cell culture process parameters on the glycation of monoclonal antibody biotherapeutics
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DOI: 10.1002/btpr.2865
Abstract: Glycation, the nonenzymatic reaction between the reducing sugar glucose and the primary amine residues on amino acid side chains, commonly occurs in the cell culture supernatant during production of therapeutic monoclonal antibodies (mAbs). While glycation… read more here.
Keywords: temperature; cell culture; process; glycation ... See more keywords
Skeletal ontogeny and deformity during the early fry culture process for Epinephelus lanceolatus
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DOI: 10.1016/j.aquaculture.2019.04.059
Abstract: Abstract Skeletal development is crucial for fish fry breeding because of its influence on fish external morphology, functional exercise, and even survival rate, especially in groupers due to their extremely high incidence of deformity and… read more here.
Keywords: epinephelus lanceolatus; fry culture; development; survival rate ... See more keywords
Upstream cell culture process characterization and in-process control strategy development at pandemic speed
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DOI: 10.1080/19420862.2022.2060724
Abstract: ABSTRACT As of early 2022, the coronavirus disease 2019 (COVID-19) pandemic remains a substantial global health concern. Different treatments for COVID-19, such as anti-COVID-19 neutralizing monoclonal antibodies (mAbs), have been developed under tight timelines. Not… read more here.
Keywords: cell culture; development pandemic; development; culture process ... See more keywords